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Your search keyword '"Hakala, M."' showing total 15 results
Start Over Author "Hakala, M." Topic sarcoma 180
15 results on '"Hakala, M."'

1. Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

Author

Yin MB, Zakrzewski SF, and Hakala MT

Subjects
Animals, Chromatography, Gel, Fibroblasts metabolism, Humans, Mice, Species Specificity, Thymidylate Synthase antagonists & inhibitors, gamma-Glutamyl Hydrolase metabolism, Carcinoma metabolism, Fluorouracil pharmacology, Folic Acid metabolism, Sarcoma 180 metabolism
Published
1983

2. Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.

Author

Domin BA, Cheng YC, and Hakala MT

Subjects
Animals, Cell Line, Drug Resistance, Electrophoresis, Polyacrylamide Gel, Folic Acid Antagonists, Humans, Isoelectric Focusing, Kinetics, Mice, Molecular Weight, Methotrexate pharmacology, Neoplasms, Experimental enzymology, Sarcoma 180 enzymology, Tetrahydrofolate Dehydrogenase metabolism
Published
1982

4. Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture.

Author

Grindey GB, Lowe JK, Divekar AY, and Hakala MT

Subjects
Animals, Cell Division drug effects, Cells, Cultured, Deoxyribonucleosides pharmacology, Dose-Response Relationship, Drug, Drug Synergism, Glycine metabolism, Guanosine analogs & derivatives, Isopentenyladenosine pharmacology, Purines biosynthesis, Guanosine pharmacology, Hypoxanthines pharmacology, Inosine analogs & derivatives, Leukemia L1210 metabolism, Methylthioinosine pharmacology, Sarcoma 180 metabolism
Abstract

The growth-inhibitory effect of 6-methylmercaptopurine riboside (MMPR) against leukemia L1210 cells in culture was dramatically potentiated by the addition of guanine nucleosides to the medium. In the presence of either deoxyguanosine or guanosine, the concentration of MMPR that caused 50% inhibition of growth was 35 times lower than in the absence of these nucleosides. Similar potentiation was also observed against Sarcoma 180 cells in culture by guanosine. The metabolic basis of this synergism was approached in a study of the incorporation of [14C]glycine into 5'-phosphoribosyl-N-formylglycinamide in Sarcoma 180 cells. The results show that the site of inhibition resulting in synergism is an early step in purine biosynthesis, probably phosphoribosyl pyrophosphate amidotransferase (EC 2.4.2.14). In the L1210 cell system, the addition of hypoxanthine to the medium prevented the potentiation of MMPR by guanine nucleosides supporting the conclusion that the site of the synergistic interaction involves purine biosynthesis de novo. While hypoxanthine partially reversed the growth-inhibitory effects of MMPR, an even higher degree of protection was observed in the presence of both uridine and hypoxanthine, suggesting that MMPR may have additional sites of action concerned with pyrimidine metabolism.

Published
1976

5. Specific protection of folate reductase against chemical and proteolytic inactivation.

Author

Hakala MT and Suolinna EM

Subjects
Animals, Chymotrypsin pharmacology, Glutamates pharmacology, Leucyl Aminopeptidase pharmacology, Purines pharmacology, Pyrimidines pharmacology, Temperature, Carboxypeptidases pharmacology, Chloromercuribenzoates pharmacology, Ethylenediamines pharmacology, Iodoacetates pharmacology, Methotrexate metabolism, Peptide Hydrolases pharmacology, Phenanthrolines pharmacology, Sarcoma 180 metabolism, Tetrahydrofolate Dehydrogenase metabolism, Trypsin pharmacology
Published
1966

7. Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.

Author

Divekar AY, Fleysher MH, Slocum HK, Kenny LN, and Hakala MT

Subjects
Alkenes metabolism, Aminohydrolases metabolism, Animals, Carbon Isotopes, Cell Division, Cells, Cultured, Chromatography, Paper, Cross Reactions, Deamination, Drug Resistance, Floxuridine metabolism, Furans metabolism, Inosine metabolism, Methotrexate pharmacology, Mice, Pentosyltransferases metabolism, Phosphotransferases metabolism, Purines, Ribonucleosides metabolism, Sarcoma 180 enzymology, Time Factors, Adenosine metabolism, Sarcoma 180 metabolism
Published
1972

10. On the nature of permeability of sarcoma-180 cells to amethopterin in vitro.

Author

Hakala MT

Subjects
Animals, Biological Transport, Active, Calcium pharmacology, Dinitrophenols pharmacology, Hydrogen-Ion Concentration, In Vitro Techniques, Leucovorin pharmacology, Riboflavin pharmacology, Temperature, Cell Membrane Permeability, Methotrexate metabolism, Sarcoma 180 metabolism, Tetrahydrofolate Dehydrogenase metabolism
Published
1965
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13. The anionic nature of sarcoma 180 cell surfaces, and sensitivity to 4,4'-diacetyldiphenylurea-bis(guanylhydrazone).

Author

Weiss L and Hakala MT

Subjects
Animals, Binding Sites, Cell Line drug effects, Depression, Chemical, Electrophoresis, Guanine therapeutic use, Hydrazines therapeutic use, In Vitro Techniques, Membrane Potentials, Mice, Neuraminidase, Ribonucleases, Antineoplastic Agents therapeutic use, Cell Membrane drug effects, Sarcoma 180 drug therapy, Surface Properties, Urea therapeutic use
Published
1971

15. Uptake and distribution of 4,4'-diacetyl-diphenyl-urea-bis-guanylhydrazone in sensitive and resistant sarcoma 180 cells in vitro.

Author

Hakala MT

Subjects
Acetamides pharmacology, Aldehydes pharmacology, Anilides pharmacology, Animals, Azo Compounds pharmacology, Biological Transport drug effects, Carbon Isotopes, Cell Fractionation, Cell Line drug effects, Cell Line growth & development, Cell Line metabolism, Cell Nucleus metabolism, Cerebrosides pharmacology, Choline pharmacology, Dinitrophenols pharmacology, Drug Synergism, Guanine metabolism, Guanine pharmacology, Hydrazines metabolism, Hydrochloric Acid pharmacology, Imidazoles pharmacology, Iodoacetates pharmacology, Kinetics, Microsomes metabolism, Mitochondria metabolism, Mutation, Phenazines pharmacology, Phosphates pharmacology, Phosphatidylcholines pharmacology, Phosphatidylethanolamines pharmacology, Phosphatidylinositols pharmacology, Polyamines pharmacology, Sodium Hydroxide pharmacology, Spermine pharmacology, Sphingomyelins pharmacology, Temperature, Thermodynamics, Vincristine pharmacology, Sarcoma 180 metabolism, Urea metabolism
Published
1971
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