Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.

Authors :: Domin BA
Cheng YC
Hakala MT
Source :: Molecular pharmacology [Mol Pharmacol] 1982 Jan; Vol. 21 (1), pp. 231-8.
Publication Year :: 1982

Subjects :: Animals
Cell Line
Drug Resistance
Electrophoresis, Polyacrylamide Gel
Folic Acid Antagonists
Humans
Isoelectric Focusing
Kinetics
Mice
Molecular Weight
Methotrexate pharmacology
Neoplasms, Experimental enzymology
Sarcoma 180 enzymology
Tetrahydrofolate Dehydrogenase metabolism

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