1. Nornostocine congeners as potential anticancer drugs: An overview.
- Author
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Sahoo, Chita R., Paidesetty, Sudhir K., and Padhy, Rabindra N.
- Subjects
- *
ANTINEOPLASTIC agents , *STRUCTURE-activity relationships , *STRUCTURAL frames , *TOXAPHENE - Abstract
The naturally occurring phyco‐constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with a remarkable anticancer activity. This review summarizes the chemistry of numerous synthetic strategies of demethylated nostocine as "nornostocine derivatives," in which the substitutes are connected to a few functionalities with the pyrazolotriazine moiety at N‐1, C‐3, and C‐5 positions. These strategies may provide a framework to design and develop a novel potent anticancer drug candidate(s) with an augment of structure activity relationship related to anticancer activities. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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