Nornostocine congeners as potential anticancer drugs: An overview.

The naturally occurring phyco‐constituent nostocine A, bearing the pyrazolotriazine scaffold in its structural frame, belongs to an organic class of pharmacologically curious candidates with a remarkable anticancer activity. This review summarizes the chemistry of numerous synthetic strategies of demethylated nostocine as "nornostocine derivatives," in which the substitutes are connected to a few functionalities with the pyrazolotriazine moiety at N‐1, C‐3, and C‐5 positions. These strategies may provide a framework to design and develop a novel potent anticancer drug candidate(s) with an augment of structure activity relationship related to anticancer activities. [ABSTRACT FROM AUTHOR]