1. PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death.
- Author
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Lee KP, Liu K, Kim EY, Medina-Puche L, Dong H, Duan J, Li M, Dogra V, Li Y, Lv R, Li Z, Lozano-Duran R, and Kim C
- Subjects
- Arabidopsis drug effects, Arabidopsis Proteins genetics, Cell Death drug effects, Cell Membrane metabolism, DNA-Binding Proteins genetics, DNA-Binding Proteins metabolism, Gene Expression Regulation, Plant drug effects, Plant Cells metabolism, Plants, Genetically Modified, Salicylic Acid pharmacology, Stress, Physiological, Transcription Factors genetics, Transcription Factors metabolism, Arabidopsis cytology, Arabidopsis metabolism, Arabidopsis Proteins metabolism, Salicylic Acid metabolism
- Abstract
The plant stress hormone salicylic acid (SA) participates in local and systemic acquired resistance, which eventually leads to whole-plant resistance to bacterial pathogens. However, if SA-mediated signaling is not appropriately controlled, plants incur defense-associated fitness costs such as growth inhibition and cell death. Despite its importance, to date only a few components counteracting the SA-primed stress responses have been identified in Arabidopsis ( Arabidopsis thaliana ). These include other plant hormones such as jasmonic acid and abscisic acid, and proteins such as LESION SIMULATING DISEASE1, a transcription coregulator. Here, we describe PLANT NATRIURETIC PEPTIDE A (PNP-A), a functional analog to vertebrate atrial natriuretic peptides, that appears to antagonize the SA-mediated plant stress responses. While loss of PNP-A potentiates SA-mediated signaling, exogenous application of synthetic PNP-A or overexpression of PNP-A significantly compromises the SA-primed immune responses. Moreover, we identify a plasma membrane-localized receptor-like protein, PNP-R2, that interacts with PNP-A and is required to initiate the PNP-A-mediated intracellular signaling. In summary, our work identifies a peptide and its putative cognate receptor as counteracting both SA-mediated signaling and SA-primed cell death in Arabidopsis., (© 2020 American Society of Plant Biologists. All rights reserved.)
- Published
- 2020
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