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PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death.
- Source :
-
The Plant cell [Plant Cell] 2020 Jul; Vol. 32 (7), pp. 2237-2250. Date of Electronic Publication: 2020 May 14. - Publication Year :
- 2020
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Abstract
- The plant stress hormone salicylic acid (SA) participates in local and systemic acquired resistance, which eventually leads to whole-plant resistance to bacterial pathogens. However, if SA-mediated signaling is not appropriately controlled, plants incur defense-associated fitness costs such as growth inhibition and cell death. Despite its importance, to date only a few components counteracting the SA-primed stress responses have been identified in Arabidopsis ( Arabidopsis thaliana ). These include other plant hormones such as jasmonic acid and abscisic acid, and proteins such as LESION SIMULATING DISEASE1, a transcription coregulator. Here, we describe PLANT NATRIURETIC PEPTIDE A (PNP-A), a functional analog to vertebrate atrial natriuretic peptides, that appears to antagonize the SA-mediated plant stress responses. While loss of PNP-A potentiates SA-mediated signaling, exogenous application of synthetic PNP-A or overexpression of PNP-A significantly compromises the SA-primed immune responses. Moreover, we identify a plasma membrane-localized receptor-like protein, PNP-R2, that interacts with PNP-A and is required to initiate the PNP-A-mediated intracellular signaling. In summary, our work identifies a peptide and its putative cognate receptor as counteracting both SA-mediated signaling and SA-primed cell death in Arabidopsis.<br /> (© 2020 American Society of Plant Biologists. All rights reserved.)
- Subjects :
- Arabidopsis drug effects
Arabidopsis Proteins genetics
Cell Death drug effects
Cell Membrane metabolism
DNA-Binding Proteins genetics
DNA-Binding Proteins metabolism
Gene Expression Regulation, Plant drug effects
Plant Cells metabolism
Plants, Genetically Modified
Salicylic Acid pharmacology
Stress, Physiological
Transcription Factors genetics
Transcription Factors metabolism
Arabidopsis cytology
Arabidopsis metabolism
Arabidopsis Proteins metabolism
Salicylic Acid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-298X
- Volume :
- 32
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Plant cell
- Publication Type :
- Academic Journal
- Accession number :
- 32409317
- Full Text :
- https://doi.org/10.1105/tpc.20.00018