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Your search keyword '"Chu GH"' showing total 3 results
Start Over Author "Chu GH" Topic receptors, opioid, kappa
3 results on '"Chu GH"'

1. Novel malonamide derivatives as potent kappa opioid receptor agonists.

Author

Chu GH, Gu M, Cassel JA, Belanger S, Graczyk TM, DeHaven RN, Conway-James N, Koblish M, Little PJ, DeHaven-Hudkins DL, and Dolle RE

Subjects
Cytochrome P-450 CYP2D6 chemistry, Drug Design, Drug Evaluation, Preclinical, Humans, Inhibitory Concentration 50, Kinetics, Malonates chemistry, Models, Chemical, Molecular Conformation, Chemistry, Pharmaceutical methods, Malonates chemical synthesis, Malonates pharmacology, Receptors, Opioid, kappa antagonists & inhibitors
Abstract

A novel series of malonamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.

Published
2007
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2. Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.

Author

Chu GH, Gu M, Cassel JA, Belanger S, Stabley GJ, DeHaven RN, Conway-James N, Koblish M, Little PJ, DeHaven-Hudkins DL, and Dolle RE

Subjects
Analgesics, Opioid pharmacology, Animals, Humans, Structure-Activity Relationship, Acetamides chemistry, Analgesics, Opioid chemistry, Aniline Compounds chemistry, Receptors, Opioid, kappa agonists
Abstract

A novel series of phenylamino acetamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.

Published
2006
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3. Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.

Author

Chu GH, Gu M, Cassel JA, Belanger S, Graczyk TM, DeHaven RN, Conway-James N, Koblish M, Little PJ, DeHaven-Hudkins DL, and Dolle RE

Subjects
Amides chemical synthesis, Amides chemistry, Animals, Benzofurans chemistry, Chromans chemical synthesis, Chromans chemistry, Humans, Amides pharmacology, Analgesics, Opioid chemistry, Analgesics, Opioid pharmacology, Chromans pharmacology, Receptors, Opioid, kappa agonists
Abstract

Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

Published
2005
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