1. The role of gamma/delta T cells in the feto-maternal relationship.
- Author
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Szekeres-Bartho J, Barakonyi A, Miko E, Polgar B, and Palkovics T
- Subjects
- Antigen Presentation, Decidua immunology, Female, HLA Antigens metabolism, Humans, In Vitro Techniques, Pregnancy, Trophoblasts immunology, Maternal-Fetal Exchange immunology, Receptors, Antigen, T-Cell, gamma-delta metabolism, T-Lymphocyte Subsets immunology
- Abstract
Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially express the V gamma 9/V delta 2 TCR, whereas those of the decidua use the V delta 1 chain. These subpopulations are functionally polarized, the former being Th1, the latter Th2. Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production., (Copyright 2001 Academic Press.)
- Published
- 2001
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