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The role of gamma/delta T cells in the feto-maternal relationship.
- Source :
-
Seminars in immunology [Semin Immunol] 2001 Aug; Vol. 13 (4), pp. 229-33. - Publication Year :
- 2001
-
Abstract
- Polymorphic MHC is absent from the trophoblast, therefore, it resists NK as well as CTL-mediated lysis in vitro. Activated gamma / delta TCR positive cells are significantly enriched in the decidua as well as in peripheral blood of healthy pregnant women. Human peripheral gamma / delta lymphocytes preferentially express the V gamma 9/V delta 2 TCR, whereas those of the decidua use the V delta 1 chain. These subpopulations are functionally polarized, the former being Th1, the latter Th2. Potentially cytotoxic V delta 2+ lymphocytes recognize HLA-E on the trophoblast via the CD94/NKG2A receptor, which induces an inhibitory signal, thus potentially inhibiting Th1 type cytokine production.<br /> (Copyright 2001 Academic Press.)
Details
- Language :
- English
- ISSN :
- 1044-5323
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Seminars in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 11437630
- Full Text :
- https://doi.org/10.1006/smim.2000.0318