1. Glycation Reactivity of a Quorum-Sensing Signaling Molecule.
- Author
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Tsuchikama K, Gooyit M, Harris TL, Zhu J, Globisch D, Kaufmann GF, and Janda KD
- Subjects
- DNA chemistry, Pentanes chemistry, Glucose chemistry, Quorum Sensing, Signal Transduction
- Abstract
Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2016
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