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Quo vadis quorum quenching?
- Source :
-
Current opinion in pharmacology [Curr Opin Pharmacol] 2013 Oct; Vol. 13 (5), pp. 688-98. Date of Electronic Publication: 2013 Jul 19. - Publication Year :
- 2013
-
Abstract
- With the emergence of microbial pathogens increasingly resistant against commonly used antibiotics, new treatment strategies are desperately needed. Bacterial quorum sensing has attracted a lot of attention over the last decade as a potential new target for antimicrobial therapy. Interference with quorum sensing signaling, or quorum quenching, might offer new avenues to prevent and/or treat bacterial infections via inhibition of virulence factor expression and biofilm formation. While many inhibitors of quorum sensing signaling have been described, only few have been evaluated in vivo and none has been clinically developed. This review will highlight recent findings and discuss interesting future areas where quorum quenching might be a promising strategy.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-4973
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current opinion in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23876839
- Full Text :
- https://doi.org/10.1016/j.coph.2013.07.003