1. The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance
- Author
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Annette Holth Skogan, Fernando Maestú, Anne-Kristin Solbakk, Kjell Heuser, Vebjørn Andersson, Erik Taubøll, Aksel Erichsen, Ira H. Haraldsen, Christoffer Hatlestad-Hall, Camillo Marra, Marte Syvertsen, Ricardo Bruña, Hanna Renvall, HUS Neurocenter, HUS Medical Imaging Center, BioMag Laboratory, HUS Diagnostic Center, University of Helsinki, University of Oslo, Technical University of Madrid, Vestre Viken Health Care Trust, Department of Neuroscience and Biomedical Engineering, Policlinico Universitario Agostino Gemelli, Aalto-yliopisto, and Aalto University
- Subjects
Male ,0301 basic medicine ,focal epilepsy ,SCR_003550 [RRID] ,SCR_004849 ,SCR_007037 ,RRID:SCR_013202 ,SCR_003550 ,Neuropsychological Tests ,SCR_004841 ,3124 Neurology and psychiatry ,source EEG ,Epilepsy ,Cognition ,0302 clinical medicine ,SALIENCE NETWORK ,SCR_004849 [RRID] ,TEMPORAL-LOBE EPILEPSY ,RRID:SCR_002510 ,EEG ,RESTING-STATE FMRI ,Default mode network ,SCR_002510 ,MEG ,SCR_004841 [RRID] ,Brain ,Middle Aged ,Magnetic Resonance Imaging ,Cognitive test ,SCR_007292 ,Settore MED/26 - NEUROLOGIA ,RRID:SCR_004849 ,SCALE BRAIN NETWORKS ,SCR_013202 [RRID] ,Female ,RRID:SCR_004841 ,SCR_007292 [RRID] ,Psychology ,RRID:SCR_003550 ,SCR_013202 ,RRID:SCR_007037 ,NEUROBEHAVIORAL COMORBIDITIES ,graph theory ,CONNECTIVITY NETWORKS ,SCR_007037 [RRID] ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,ADULT EPILEPSY ,Social cognition ,medicine ,Humans ,Effects of sleep deprivation on cognitive performance ,RRID ,cognitive impairment ,Resting state fMRI ,functional connectivity ,3112 Neurosciences ,RRID:SCR_007292 ,medicine.disease ,SCR_002510 [RRID] ,030104 developmental biology ,DEFAULT MODE NETWORK ,neurocognitive networks ,Epilepsies, Partial ,Nerve Net ,Neuroscience ,Neurocognitive ,030217 neurology & neurosurgery - Abstract
Funding Information: This project is funded by the South‐Eastern Norway Regional Health Authority, project number 2016033, and is in partnership with the Centre for Digital Life Norway, supported by the Research Council of Norway's grant 248810. Publisher Copyright: © 2021 The Authors. Journal of Neuroscience Research published by Wiley Periodicals LLC. Understanding and diagnosing cognitive impairment in epilepsy remains a prominent challenge. New etiological models suggest that cognitive difficulties might not be directly linked to seizure activity, but are rather a manifestation of a broader brain pathology. Consequently, treating seizures is not sufficient to alleviate cognitive symptoms, highlighting the need for novel diagnostic tools. Here, we investigated whether the organization of three intrinsic, resting-state functional connectivity networks was correlated with domain-specific cognitive test performance. Using individualized EEG source reconstruction and graph theory, we examined the association between network small worldness and cognitive test performance in 23 patients with focal epilepsy and 17 healthy controls, who underwent a series of standardized pencil-and-paper and digital cognitive tests. We observed that the specific networks robustly correlated with test performance in distinct cognitive domains. Specifically, correlations were evident between the default mode network and memory in patients, the central-executive network and executive functioning in controls, and the salience network and social cognition in both groups. Interestingly, the correlations were evident in both groups, but in different domains, suggesting an alteration in these functional neurocognitive networks in focal epilepsy. The present findings highlight the potential clinical relevance of functional brain network dysfunction in cognitive impairment.
- Published
- 2021