1. Biocompatible and fluorescent superparamagnetic iron oxide nanoparticles with superior magnetic properties coated with charged polysaccharide derivatives.
- Author
-
Lachowicz D, Szpak A, Malek-Zietek KE, Kepczynski M, Muller RN, Laurent S, Nowakowska M, and Zapotoczny S
- Subjects
- Animals, Cell Line, Cell Membrane metabolism, Contrast Media chemistry, Curcumin chemistry, Endothelial Cells drug effects, Fluorescent Dyes chemistry, Humans, Hyaluronic Acid chemistry, Light, Magnetic Resonance Imaging, Magnetics, Mice, NIH 3T3 Cells, Scattering, Radiation, Spectrometry, Fluorescence, Spectrophotometry, Biocompatible Materials chemistry, Dextrans chemistry, Ferric Compounds chemistry, Magnetite Nanoparticles chemistry, Polysaccharides chemistry
- Abstract
Syntheses and characterizations of biocompatible superparamagnetic iron oxide nanoparticles with embedded curcumin and coated with ultrathin layer of hyaluronic acid-curcumin (HA-Cur) conjugate have been reported. Zeta potential measurements confirmed effective coating of native iron oxide nanoparticles stabilized by cationic derivative of chitosan (SPION-CCh) with the synthesized HA-Cur conjugate. Both SPIONs with embedded curcumin and the ones coated with HA-Cur (SPION-CCh/HA-Cur) revealed desired magnetic characteristics while fluorescent properties were much better for the coated nanoparticles. SPION-CCh/HA-Cur nanoparticles were shown to be very promising candidates for T
2 MRI contrast agents as they can easily penetrate cell membrane and their relaxivity is exceptionally high (ca. 470mM-1 s-1 ). They may be also tracked using confocal fluorescence microscopy due to the presence of fluorescent curcumin in the coating. In vitro studies indicated that the obtained SPIONs-CCh/HA-Cur were non-toxic for EA.hy926 endothelial cells., (Copyright © 2016 Elsevier B.V. All rights reserved.)- Published
- 2017
- Full Text
- View/download PDF