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Biocompatible and fluorescent superparamagnetic iron oxide nanoparticles with superior magnetic properties coated with charged polysaccharide derivatives.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2017 Feb 01; Vol. 150, pp. 402-407. Date of Electronic Publication: 2016 Nov 02. - Publication Year :
- 2017
-
Abstract
- Syntheses and characterizations of biocompatible superparamagnetic iron oxide nanoparticles with embedded curcumin and coated with ultrathin layer of hyaluronic acid-curcumin (HA-Cur) conjugate have been reported. Zeta potential measurements confirmed effective coating of native iron oxide nanoparticles stabilized by cationic derivative of chitosan (SPION-CCh) with the synthesized HA-Cur conjugate. Both SPIONs with embedded curcumin and the ones coated with HA-Cur (SPION-CCh/HA-Cur) revealed desired magnetic characteristics while fluorescent properties were much better for the coated nanoparticles. SPION-CCh/HA-Cur nanoparticles were shown to be very promising candidates for T <subscript>2</subscript> MRI contrast agents as they can easily penetrate cell membrane and their relaxivity is exceptionally high (ca. 470mM <superscript>-1</superscript> s <superscript>-1</superscript> ). They may be also tracked using confocal fluorescence microscopy due to the presence of fluorescent curcumin in the coating. In vitro studies indicated that the obtained SPIONs-CCh/HA-Cur were non-toxic for EA.hy926 endothelial cells.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cell Line
Cell Membrane metabolism
Contrast Media chemistry
Curcumin chemistry
Endothelial Cells drug effects
Fluorescent Dyes chemistry
Humans
Hyaluronic Acid chemistry
Light
Magnetic Resonance Imaging
Magnetics
Mice
NIH 3T3 Cells
Scattering, Radiation
Spectrometry, Fluorescence
Spectrophotometry
Biocompatible Materials chemistry
Dextrans chemistry
Ferric Compounds chemistry
Magnetite Nanoparticles chemistry
Polysaccharides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 150
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 27842931
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2016.11.003