1. Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020.
- Author
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Santos-Hövener C, Neuhauser HK, Rosario AS, Busch M, Schlaud M, Hoffmann R, Gößwald A, Koschollek C, Hoebel J, Allen J, Haack-Erdmann A, Brockmann S, Ziese T, Nitsche A, Michel J, Haller S, Wilking H, Hamouda O, Corman VM, Drosten C, Schaade L, Wieler LH, and Lampert T
- Subjects
- Adolescent, Adult, Aged, COVID-19, Coronavirus Infections epidemiology, Disease Outbreaks prevention & control, Enzyme-Linked Immunosorbent Assay, Female, Germany epidemiology, Humans, Immunoglobulin G, Incidence, Male, Middle Aged, Pandemics prevention & control, Pneumonia, Viral epidemiology, Population Surveillance, SARS-CoV-2, Seroepidemiologic Studies, Serologic Tests, COVID-19 Nucleic Acid Testing, COVID-19 Serological Testing, Coronavirus genetics, Coronavirus isolation & purification, Coronavirus Infections diagnosis, Pneumonia, Viral diagnosis, Polymerase Chain Reaction methods
- Abstract
Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5-9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4-14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk.
- Published
- 2020
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