1. Plasmodium knowlesi: a relevant, versatile experimental malaria model.
- Author
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Pasini EM, Zeeman AM, Voorberg-VAN DER Wel A, and Kocken CHM
- Subjects
- Adaptation, Biological, Animals, Erythrocytes parasitology, Humans, Macaca fascicularis, Macaca mulatta, Malaria immunology, Malaria prevention & control, Malaria veterinary, Malaria Vaccines analysis, Malaria Vaccines pharmacology, Monkey Diseases immunology, Monkey Diseases parasitology, Monkey Diseases prevention & control, Plasmodium knowlesi immunology, Zoonoses immunology, Zoonoses parasitology, Zoonoses prevention & control, Disease Models, Animal, Haplorhini, Host-Parasite Interactions, Malaria parasitology, Plasmodium knowlesi physiology
- Abstract
The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite-host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that P. knowlesi is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.
- Published
- 2018
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