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Plasmodium knowlesi: a relevant, versatile experimental malaria model.
- Source :
-
Parasitology [Parasitology] 2018 Jan; Vol. 145 (1), pp. 56-70. Date of Electronic Publication: 2016 Dec 12. - Publication Year :
- 2018
-
Abstract
- The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite-host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that P. knowlesi is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.
- Subjects :
- Adaptation, Biological
Animals
Erythrocytes parasitology
Humans
Macaca fascicularis
Macaca mulatta
Malaria immunology
Malaria prevention & control
Malaria veterinary
Malaria Vaccines analysis
Malaria Vaccines pharmacology
Monkey Diseases immunology
Monkey Diseases parasitology
Monkey Diseases prevention & control
Plasmodium knowlesi immunology
Zoonoses immunology
Zoonoses parasitology
Zoonoses prevention & control
Disease Models, Animal
Haplorhini
Host-Parasite Interactions
Malaria parasitology
Plasmodium knowlesi physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-8161
- Volume :
- 145
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 27938428
- Full Text :
- https://doi.org/10.1017/S0031182016002286