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Introduction: Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. Objectives: To assess associations of sedentary behavior with depression and anxiety symptoms and estimate the impact of replacing daily time spent in sedentary behaviors with sleep, light, or moderate-to-vigorous physical activity, using novel compositional data analysis methods. Methods: Prospective cohort study in with 60,235 UK Biobank participants (mean age: 56; 56%female). Exposure was baseline daily movement behaviours (accelerometer-assessed sedentary behaviour, physical activity, and self-reported total sleep). Outcomes were depression and anxiety symptoms (Patient Health Questionnaire-9 and Generalised Anxiety Disorders-7) at follow up. Results: Replacing 60 minutes of sedentary behaviour with light activity, moderate-to-vigorous activity, and sleep was associated with lower depression symptom scores by 1.3% (95%CI, 0.4%-2.1%), 12.5% (95%CI, 11.4%-13.5%), and 7.6% (95%CI, 6.9%-8.4%), and lower odds of depression by 0.95 (95%CI, 0.94-0.96), 0.75 (95%CI, 0.74-0.76), and 0.90 (95%CI, 0.90-0.91) at follow-up. Replacing 60 minutes of sedentary behaviour with moderate-tovigorous activity and sleep was associated with lower anxiety symptom scores by 6.6% (95%CI, 5.5%-7.6%) and 4.5% (95%CI, 3.7%-5.2%), and lower odds of meeting the threshold for an anxiety disorder by 0.90 (95%CI, 0.89-0.90) and 0.97 (95%CI, 0.96-0.97) at follow-up. However, replacing 60 minutes of sedentary behaviour with light activity was associated with higher anxiety symptom scores by 4.5% (95%CI, 3.7%-5.3%) and higher odds of an anxiety disorder by 1.07 (95%CI, 1.06-1.08). Conclusions: Sedentary behaviour is a risk factor for increased depression and anxiety symptoms in adults, but different replacement activities differentially influence mental health. [ABSTRACT FROM AUTHOR]

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Copyright of Revista Kronos is the property of Revista Kronos and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary Objective To determine the influence of the level of physical activity on physical fitness, body composition and lipid profile and further explore the associations between fitness with these health outcomes in a population of overweight/obese adults. Methods Forty overweight/obesity participants with a caloric intake between a negative balance of 500 kcal/day and their estimated required energy intake were classified according to their level of physical activity. Anthropometric (weight and height), body composition (waist-to-hip ratio, percentage of body fat and fat-free mass), clinical measurements (blood pressure), physical fitness (cardiorespiratory fitness – 6MWT –, handgrip strength and lower-limb muscle strength – MVC –) and lipid profile (total cholesterol – TC –, low – LDL – and high-density lipoprotein cholesterol – HDL –, triglyceride – TG –, and plasma glucose) were determined. Results Significant differences in MVC and fat-free mass were found between participants with different physical level. Significant associations between all the body composition measures and the strength-related variables (handgrip and MVC) in both physical activity categories also were found. In addition, associations between triglycerides, LDL and total cholesterol with muscle strength and cardiorespiratory fitness were observed only in the low physical activity group. Moreover, MVC explained up to 39% of the variance in metabolic syndrome in those with a moderate level of physical activity. Conclusions Correlations between physical fitness (especially in strength) and health risk factors depending on the level of physical activity were found. [ABSTRACT FROM AUTHOR]