24-hour movement behaviours and the risk of common mental health symptoms: A compositional analysis in the UK biobank.

Introduction: Sedentary behaviour is potentially a modifiable risk factor for depression and anxiety disorders, but findings have been inconsistent. Objectives: To assess associations of sedentary behavior with depression and anxiety symptoms and estimate the impact of replacing daily time spent in sedentary behaviors with sleep, light, or moderate-to-vigorous physical activity, using novel compositional data analysis methods. Methods: Prospective cohort study in with 60,235 UK Biobank participants (mean age: 56; 56%female). Exposure was baseline daily movement behaviours (accelerometer-assessed sedentary behaviour, physical activity, and self-reported total sleep). Outcomes were depression and anxiety symptoms (Patient Health Questionnaire-9 and Generalised Anxiety Disorders-7) at follow up. Results: Replacing 60 minutes of sedentary behaviour with light activity, moderate-to-vigorous activity, and sleep was associated with lower depression symptom scores by 1.3% (95%CI, 0.4%-2.1%), 12.5% (95%CI, 11.4%-13.5%), and 7.6% (95%CI, 6.9%-8.4%), and lower odds of depression by 0.95 (95%CI, 0.94-0.96), 0.75 (95%CI, 0.74-0.76), and 0.90 (95%CI, 0.90-0.91) at follow-up. Replacing 60 minutes of sedentary behaviour with moderate-tovigorous activity and sleep was associated with lower anxiety symptom scores by 6.6% (95%CI, 5.5%-7.6%) and 4.5% (95%CI, 3.7%-5.2%), and lower odds of meeting the threshold for an anxiety disorder by 0.90 (95%CI, 0.89-0.90) and 0.97 (95%CI, 0.96-0.97) at follow-up. However, replacing 60 minutes of sedentary behaviour with light activity was associated with higher anxiety symptom scores by 4.5% (95%CI, 3.7%-5.3%) and higher odds of an anxiety disorder by 1.07 (95%CI, 1.06-1.08). Conclusions: Sedentary behaviour is a risk factor for increased depression and anxiety symptoms in adults, but different replacement activities differentially influence mental health. [ABSTRACT FROM AUTHOR]