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Aim of the Study: Apart from empirically learned medicinal and pharmacological properties, the selection of medicinal plants is dependent on cognitive features, ecological factors and cultural history. In literate societies the transmission of medicinal plant knowledge through texts and, more recently, other media containing local as well as non-local knowledge has a more immediate and a more prolonged effect than oral transmission. Therefore, I try to visualize how field based studies in ethnobiology and especially medical ethnobotany and ethnopharmacology run the risk of repeating information and knowledge and illustrate the importance of differentiating and acknowledging the origin, transmission and rationale of plant use made by humans., Materials and Methods: Reviewing literature dealing with the traditional parameters (e.g. hot/cold dichotomy, organoleptic properties, doctrine of signatures) influencing the selection and transmission of plant use in a juxtaposition to our recent finding of causal influence of text on local plant use. Discussing the passing down of knowledge by text as a special case of oblique/one-to-many knowledge transmission., Results: Historical texts on materia medica, popular books on plant use, clinical studies, and informants of ethnobotanical field studies generate a circle of information and knowledge, which progressively conditions the results of ethnobotanical field studies. While text reporting on phytotherapeutical trends may cause innovation through the introduction of "new" applications to local customs, persistently repeating well established folk remedies leads to the consolidation of such uses adding a conservative dimension to a local pharmacopoeia, which might not actually be there to that extent., Conclusions: Such a "shaping" of what might appear to be the results of a field investigation is clearly outside the ordinary principles of scientific enquiry. The traditional pillars of ethnobotanical field studies - that is, "input to drug discovery" and "conservation of cultural heritage" - are also incompatible with this process. Ethnobotancial field studies aimed at a contribution to natural products research and/or the conservation of cultural heritage, as well as those aimed at an assessment and validation of local pharmacopoeias should differentiate between local plant use and widespread as well as modern knowledge reported in popular textbooks and scientific literature., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

The authors aim to shed light on the pathways for recovery from problematic use of psychoactive substances when a psychoactive substance turns out to be, paradoxically, the medicine. Keywords: psychedelic; ritual; ayahuasca; plant medicine; psychoactive drugs EN psychedelic ritual ayahuasca plant medicine psychoactive drugs 1 3 3 12/08/21 20211203 NES 211203 The Research Topic here presented is based on first-hand clinical experiences and ethnographic and observational fieldwork studies on practices used or inspired by traditional medicines related in particular to the so-called psychedelics; these are substances known to trigger non-ordinary states of consciousness, which are currently getting more attention in medicine as reflected by the increase in clinical research and a shift in attitude and opinion among public spheres. [Extracted from the article]

Ethnopharmacological relevance Written history allows tracing back Mediterranean and European medical traditions to Greek antiquity. The epidemiological shift triggered by the rise of modern medicine and industrialization is reflected in contemporary reliance and preferences for certain herbal medicines. Materials and methods We sketch the development and transmission of written herbal medicine through Mediterranean and European history and point out the opportunity to connect with modern traditions. Results An ethnopharmacological database linking past and modern medical traditions could serve as a tool for crosschecking contemporary ethnopharmacological field-data as well as a repository for data mining. Considering that the diachronic picture emerging from such a database has an epidemiological base this could lead to new hypotheses related to evolutionary medicine. Conclusion The advent of systems pharmacology and network pharmacology opens new perspectives for studying past and current herbal medicine. Since a large part of modern drugs has its roots in ancient traditions one may expect new leads for drug development from novel systemic studies, as well as evidence for the activity of certain herbal preparations. [ABSTRACT FROM AUTHOR]

As an interdisciplinary field of research ethnopharmacology draws on methodologies and methods from a variety of disciplines. A range of ethnobotanical indices are frequently used to transform primary data obtained through field studies into statistical measures. These indices are claimed to serve as a proxy for efficacy or drug discovery (Fidelity Level 'FL') and to show the importance of botanical drugs and plants used as medicines (Relative Importance 'RI', Use Value 'UV' or Cultural Importance Index 'CI', Cultural Value Index 'CV', Relative Frequency of Citation 'RFC'). This is, however, doubtful, as these indices have not been developed by statisticians, nor by pharmacologists while a proof of concept is lacking. Moreover, the question whether a simple number can summarize the cultural value or importance of plants is not only mathematical but also epistemological. The FL, RI, UV/CI, CV and the RFC are shortly reviewed. Their statistical rigour is explained and the relevance for ethnobotany, ethnopharmacology and drug discovery discussed. The effect of the sample size on the dispersal of data and the differential probability of botanical drugs being used for the different categories of use are not being considered by these indices. They lack statistical rigour and are simple percentage calculations. Moreover, important factors influencing plant use, such as the availability of pharmaceutical drugs, or the severity of diseases covered by the use-categories, are not accounted for. Especially unexperienced and young researchers may be ensnared by using ethnobotanical indices to describe their field data. However, the cultural value and importance of plants in general, and more specifically, of medicinal plants and botanical drugs cannot be summed up by numbers. The discussed indices encrypt parts of the primary data but fail to show the value or importance of plant use because the reasons for which plants are valued or important to people are far more complex than what the formulations of these indices suggest. The indices also lack the power to pinpoint plant species or botanical drugs for drug discovery that contextualized primary data has. Botanical drugs may be useful for a range of disorders or only for specific indications, according to their pharmacologic properties. Therefore, the exclusiveness of therapeutical applications (FL) does not serve as a proxy for effectiveness. The solution is to use and understand the contextualized primary data. [Display omitted] [ABSTRACT FROM AUTHOR]

There are longstanding traditions of animal-derived products being employed as medicines, and they continue to be important in many traditional cultural healthcare practices. However, the populations of numerous so-used animals are known to be threatened with extirpation by such practices. Ethnopharmacological studies documenting these animal-derived drugs are not only interesting from an anthropological standpoint, but they are also relevant from a wildlife conservation perspective – especially since ethnopharmacologists are intermediaries between indigenous and scientific communities, placing them at the forefront of being able to ethically access information to address these issues. Using the example of documenting culturally acceptable substitute materials for animal products (which ultimately also extends to flora), we explore the intersection of ethnopharmacology, biocultural resources, and wildlife conservation. Pharmacological efficacy and symbolism are factors influencing the utilization of traditional medicines. Achieving the integration of conservation aims with ethnopharmacology requires a nuanced understanding of both factors, along with fair adjudication when conservation and cultural aims diverge. Ethnopharmacology is suitably placed for making conservation-orientated recommendations – including investigating more sustainable substitutes for animal products in the context of medical efficacy, and for engaging ethically with local communities to facilitate information generation aimed at protecting the environment and their traditions. We suggest an integrative approach to ethnopharmacological studies investigating medicinal bioresource use. This approach is considerate of species' conservation profiles, the substitutability and pharmacological efficacy of biocultural resources, indigenous and cultural rights, and a collaborative ethos for stakeholder engagement. [Display omitted] [ABSTRACT FROM AUTHOR]

The genus Orobanche consists of annual, biennial or perennial fleshy parasitic herb species, many of which are in use as traditional medicines and wild gathered foods since a long time. Recently, Orobanche spp. are increasingly accepted as edible medicines with nourishing properties. However, there is a lack of comprehensive understanding of their ethnopharmacological background. Aim of the review : This review focuses on the advancements in botanical classification, and summary of traditional use, phytochemistry, pharmacology and toxicology of Orobanche species, in order to check for scientific support of their traditional uses and the safe treatment of human ailments and diseases. In this review, the results of a systematic and comprehensive literature survey about Orobanche spp over the past 60 years (from 1960 to 2020) is presented. The selected literature includes periodicals, doctoral dissertations, master dissertations conference papers and various books. The literature was identified through search engine websites and a cross-checked with the Chinese pharmacopeia, classic Chinese and European herbals, regional medicinal monographs, and online ethnobotanical databases. The literature about the traditional uses revealed that Orobanche spp. were used as medicine and food in many regions of the world, but mainly in China and North America while in Europe they were primarily used as food items. Phenylpropanoid derivatives and alkaloids, were reported as their main bioactive compounds, showing antioxidant, immune system enhancing, androgenic, antibacterial and antiviral properties. Orobanche spp. are increasingly being used for tonic purposes in China. Their ethnopharmacological background suggests potential usages as healthy foods and food supplements. They have the potential to be developed into herbal medicines for tonifying the kidney, against impotence and spermatorrhea, dermatological problems and wounds, as well as infantile diarrhoea. However, the pharmacological studies conducted with extracts derived from Orobanche spp. were not useful for rationally explaining the traditional uses. More investigations are required to provide a pharmacological basis for the traditional claims and the relationship between traditional uses, clinical uses, phytochemistry and pharmacological properties. Additionally, quality control should be emphasized to ensure the safe and effective use of Orobanche derived products. Image 1 [ABSTRACT FROM AUTHOR]