1. Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer.
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Elhusseiny, Khaled Mosaad, Abd‐Elhay, Fatma Abd‐Elshahed, Kamel, Mohamed Gomaa, Abd El Hamid Hassan, Heba Hassan, El Tanany, Heba Hussien Muhammad, Hieu, Truong Hong, Tieu, Thuan Minh, Low, Soon Khai, Hou, Vincent, Dibas, Mahmoud, and Huy, Nguyen Tien
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SALIVARY gland cancer ,LYMPH nodes ,SUBMANDIBULAR gland ,PAROTID glands - Abstract
Background: We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNs×100) in patients with major salivary gland cancer (SGC). Methods: Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program. Results: We have included 5446 patients with major SGC. Most patients had parotid gland cancer (84.61%). Patients having >18 ELNs, >4 PLNs, and >33.33% LNR were associated with a worse survival. Moreover, older age, male patients, grade IV, distant stage, unmarried patients, submandibular gland cancer, and received chemotherapy but not received surgery were significantly associated with a worse survival. Conclusions: We demonstrated that patients with >18 ELNs and >4 PLNs counts, and >33.33% LNR were high‐risk group patients. We strongly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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