1. Apolipoprotein A1 as a potential biomarker in the ascitic fluid for the differentiation of advanced ovarian cancers.
- Author
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Hariprasad, Gururao, Hariprasad, Roopa, Kumar, Lalit, Srinivasan, Alagiri, Kola, Srujana, and Kaushik, Amit
- Subjects
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OVARIAN cancer , *APOLIPOPROTEIN A , *BIOMARKERS , *METASTASIS , *CANCER treatment , *PROTEOMICS , *BIOLOGICAL assay research - Abstract
Context: Primary ovarian cancer and ovarian metastasis from non-ovarian cancers in advanced stage are closely mimicking conditions whose therapeutics and prognosis are different. Objective: To identify biomarkers that can differentiate the two variants of advanced ovarian cancers. Methods: Gel-based proteomics and antibody-based assays were used to study the differentially expressed proteins in the ascitic fluid of fourteen patients with advanced ovarian cancers. Results: Programmed Cell Death 1-Ligand 2, apolipoprotein A1, apolipoprotein A4 and anti-human fas antibody are differentially expressed proteins. Conclusions: Apolipoprotein A1 with a 61.8ng/ml cut-off is a potential biomarker with the best differentiating statistical parameters. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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