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Apolipoprotein A1 as a potential biomarker in the ascitic fluid for the differentiation of advanced ovarian cancers.
- Source :
-
Biomarkers . Sep2013, Vol. 18 Issue 6, p532-541. 10p. 2 Charts. - Publication Year :
- 2013
-
Abstract
- Context: Primary ovarian cancer and ovarian metastasis from non-ovarian cancers in advanced stage are closely mimicking conditions whose therapeutics and prognosis are different. Objective: To identify biomarkers that can differentiate the two variants of advanced ovarian cancers. Methods: Gel-based proteomics and antibody-based assays were used to study the differentially expressed proteins in the ascitic fluid of fourteen patients with advanced ovarian cancers. Results: Programmed Cell Death 1-Ligand 2, apolipoprotein A1, apolipoprotein A4 and anti-human fas antibody are differentially expressed proteins. Conclusions: Apolipoprotein A1 with a 61.8ng/ml cut-off is a potential biomarker with the best differentiating statistical parameters. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 18
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 90258578
- Full Text :
- https://doi.org/10.3109/1354750X.2013.822561