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Method describes asymmetric reaction of triethyl phosphites and 2-arylidenemalononitrile catalysed by the chiral organocatalyst in solvent ethanol. The organocatalyst effectively catalyse reaction to give β-malonophosphonates in high yields (85–64%) and good to moderate enantiomeric excess (78–53%).

This present method deals with an exceedingly rare aspect of α-aminophosphonate synthesis. We studied an enantioseletive one-pot synthetic method for the syntheses of optically active α-aminophosphonates by employing an organocatalyst. Some new organocatalysts were synthesized and studied for their reactivity and enantioselectivity. The organocatalyst effectively catalyzed the reaction and provided the corresponding α-aminophosphonates in high yields (71–90 %) with excellent enantiomeric excess values (73–92 %).

Using hydrogen bond based concept we have synthesized new organocatalysts and have applied them to catalyze direct asymmetric aldol reaction. Reaction proceeded efficiently and gave high yield with excellent diastereoselectivity and enantioselectivity.

Phospha—Michael addition of P(O—Et)3 to benzylidenemalononitriles (I) in the presence of a proline-based organocatalyst represents one of the most straightforward routes for the synthesis of optically active β-malonophosphonates (III) (13 examples).

This present method deals with an exceedingly rare aspect of α-aminophosphonate synthesis. We studied an enantioseletive one-pot synthetic method for the syntheses of optically active α-aminophosphonates by employing an organocatalyst. Some new organocatalysts were synthesized and studied for their reactivity and enantioselectivity. The organocatalyst effectively catalyzed the reaction and provided the corresponding α-aminophosphonates in high yields (71–90 %) with excellent enantiomeric excess values (73–92 %).

A novel and eco-friendly method for the asymmetric Henry reaction of aldehydes is developed.

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3-chlorophenylboronic acid as a catalyst under ambient temperature conditions. The three-component reaction of indoles, aromatic aldehydes and N -methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields. This protocol presents some remarkable features such as mild reaction conditions, simple workup procedure and excellent yields.

A series of new organocatalysts is designed based on hydrogen bonding motifs and applied to the title reaction.

We report an enantioselective Henry (nitroaldol) reaction catalysed by an organocatalyst using water as solvent. The enantioselective synthesis of β-nitroalcohols was achieved by using a neutral chiral organocatalyst, through strong hydrogen bonding, which results in the formation of corresponding products in excellent yield and enantioselectivity at room temperature. Other attractive features of the method are the eco-friendly, non-hazardous, and mild reaction conditions, inexpensive catalyst, and simple work up conditions.