An Efficient Organocatalysis: A One-Pot Highly Enantioselective Synthesis of α-Aminophosphonates

This present method deals with an exceedingly rare aspect of α-aminophosphonate synthesis. We studied an enantioseletive one-pot synthetic method for the syntheses of optically active α-aminophosphonates by employing an organocatalyst. Some new organocatalysts were synthesized and studied for their reactivity and enantioselectivity. The organocatalyst effectively catalyzed the reaction and provided the corresponding α-aminophosphonates in high yields (71–90 %) with excellent enantiomeric excess values (73–92 %).