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Your search keyword '"Zhu, Chongjie"' showing total 1 results
Start Over Author "Zhu, Chongjie" Topic organic acids
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1. A Highly Convergent Synthesis of 2‐Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors.

Author

Yan, Hongxing, Kerns, JeffreyK., Jin, Qi, Zhu, Chongjie, Barnette, MaryS., Callahan, JamesF., Hay, DouglasW. P., Jolivette, LarryJ., Luttmann, MarkA., Sarau, HenryM., Ward, KeithW., Widdowson, KatherineL., and Wan, Zehong

Subjects
CYCLOHEXANE, ALICYCLIC compounds, PIPERAZINE, CARBOXYLIC acids, ORGANIC acids
Abstract

A novel and highly convergent synthesis leading to 2‐phenyl‐quinolines has been developed. As demonstrated in the preparation of 6‐fluoro‐3‐(3‐oxo‐piperazin‐1‐ylmethyl)‐2‐phenyl‐quinoline‐4‐carboxylic acid [(S)‐1‐cyclohexyl‐ethyl]‐amide (8), the method provides fascile access to this class of analogues via the common intermediate 7. [ABSTRACT FROM AUTHOR]

Published
2005
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