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A Highly Convergent Synthesis of 2‐Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors.
- Source :
- Synthetic Communications; 2005, Vol. 35 Issue 24, p3105-3112, 8p, 2 Diagrams, 1 Chart
- Publication Year :
- 2005
-
Abstract
- A novel and highly convergent synthesis leading to 2‐phenyl‐quinolines has been developed. As demonstrated in the preparation of 6‐fluoro‐3‐(3‐oxo‐piperazin‐1‐ylmethyl)‐2‐phenyl‐quinoline‐4‐carboxylic acid [(S)‐1‐cyclohexyl‐ethyl]‐amide (8), the method provides fascile access to this class of analogues via the common intermediate 7. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYCLOHEXANE
ALICYCLIC compounds
PIPERAZINE
CARBOXYLIC acids
ORGANIC acids
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 35
- Issue :
- 24
- Database :
- Complementary Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 19020428
- Full Text :
- https://doi.org/10.1080/00397910500281234