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Researchers at Zhejiang University in China have identified fibronectin 1 (FN1) as a reliable prognostic biomarker for thyroid cancer, particularly medullary carcinoma and undifferentiated carcinoma. The study analyzed RNA-sequencing data from The Cancer Genome Atlas and Genotype-Tissue Expression databases, finding that higher FN1 expression levels were associated with advanced tumor stages and poor prognosis in thyroid cancer patients. The research suggests that FN1 could be a potential biomarker and therapeutic target for thyroid cancer, playing a role in immune infiltration in the disease. [Extracted from the article]

A recent study published in Thyroid Research and Practice discusses the case of a 29-year-old female patient with medullary thyroid cancer (MTC) and high calcitonin levels, which presented a therapeutic challenge. The patient underwent total thyroidectomy and neck dissection, followed by treatment with carbozantinib chemotherapy. However, there was no significant benefit in biochemical response, and the patient developed secondary amenorrhea. The study highlights the importance of calcitonin measurement in predicting response to therapy and as a marker of persisting disease. It also emphasizes the need for genetic analysis in MTC for risk stratification and screening of family members. Additionally, the study mentions the rare occurrence of ovarian insufficiency after chemotherapy and advises women of reproductive age to consider oocyte preservation. [Extracted from the article]

A recent study conducted at the University of Texas MD Anderson Cancer Center in Houston has highlighted the potential benefits of radiation therapy in the management of renal medullary carcinoma (RMC), a rare and aggressive cancer primarily affecting young individuals of African descent with sickle cell trait. Unlike other renal cancers, RMC has a poor prognosis and limited response to standard treatments. The study found that combining radiation therapy with systemic therapies can significantly improve outcomes, with some patients experiencing over 12 months of disease-free survival. The findings suggest that an aggressive, personalized, and multimodal approach, including early integration of radiation therapy with systemic therapy, may be beneficial in treating RMC. Further research is needed to validate these findings and refine the integration of radiation therapy in RMC treatment. [Extracted from the article]

A new report presents fresh data on medullary cancer, a rare subtype of adenocarcinoma. The study conducted by researchers at MBBS compared data from their patient population with the current literature. They found that medullary carcinoma of the colon is associated with mismatch gene repair and has a favorable prognosis compared to poorly differentiated cancers. The study also revealed that the majority of patients in their cohort were female and had lymphovascular invasion. The researchers concluded that longer follow-up is needed to determine survival outcomes. [Extracted from the article]

A recent study conducted at the Memorial Sloan-Kettering Cancer Center in New York City has reported new findings on medullary cancer. The study focuses on specific subtypes of high-grade renal cell carcinoma (RCC), including fumarate hydratase (FH)-deficient RCC, anaplastic lymphoma kinase (ALK)-rearranged RCC, and SMARCB1-deficient renal medullary carcinoma. These subtypes are now recognized as molecularly defined entities in the WHO classification system. The research emphasizes the importance of integrating molecular findings into diagnostic paradigms and calls for continued research to enhance diagnostic precision and therapeutic options for these uncommon types of RCC. [Extracted from the article]

A recent report from the Dr. B. Borooah Cancer Institute in Assam, India, discusses the occurrence of collision tumors in the thyroid. Collision tumors are characterized by the simultaneous presence of two distinct malignant tumors in the same organ. The report presents three cases of collision tumors in the thyroid, including combinations of follicular neoplasm with hurthle cell carcinoma, hurthle cell neoplasm with papillary thyroid carcinoma, and medullary carcinoma. The study emphasizes the diagnostic and therapeutic challenges posed by collision tumors and highlights the importance of extensive sampling to identify co-existing neoplasms. [Extracted from the article]

A recent study conducted by researchers at Howard University focused on renal medullary carcinoma (RMC), an aggressive and rare form of kidney cancer that primarily affects Black patients but can also occur in individuals of other ethnicities. The study aimed to identify predictors of mortality and overall survival outcomes in patients with RMC. The researchers analyzed data from the Surveillance, Epidemiology, and End Results (SEER) Program database and found that Black patients with RMC had a lower survival rate and were less likely to receive surgery compared to their White counterparts. The study highlights the disproportionate impact of RMC on Black patients and the need for further research on the disease. [Extracted from the article]

Researchers from Valduce Hospital in Como, Italy have reported on the findings of a study on colorectal medullary carcinoma (CMC), a rare subset of minimally differentiated carcinomas. The study found that CMC tends to be right-sided and present at an advanced stage, although distant metastases are rare at presentation. The liver and regional lymph nodes are the most common sites of metastases. The study also highlighted the lack of data on treatment strategies and short-term outcomes for CMC, as well as the diagnostic uncertainty and overtreatment that can result from its heterogeneous presentations and unclear prognostic significance. The researchers aim to bring attention to this rare histological subtype through the report of two cases. [Extracted from the article]

Calcitonin, Cancer, Carcinomas, Halogens, Health and Medicine, Hormones, Iodine, Medullary Cancer, Medullary Carcinoma, Oncology, Risk and Prevention Keywords: Calcitonin; Cancer; Carcinomas; Halogens; Health and Medicine; Hormones; Iodine; Medullary Cancer; Medullary Carcinoma; Oncology; Risk and Prevention EN Calcitonin Cancer Carcinomas Halogens Health and Medicine Hormones Iodine Medullary Cancer Medullary Carcinoma Oncology Risk and Prevention 877 877 1 07/03/23 20230704 NES 230704 2023 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Current study results on medullary cancer have been published. [Extracted from the article]

Keywords: Cancer; Carcinomas; Health and Medicine; Kidney; Medullary Cancer; Medullary Carcinoma; Nephrology; Oncology EN Cancer Carcinomas Health and Medicine Kidney Medullary Cancer Medullary Carcinoma Nephrology Oncology 308 308 1 06/12/23 20230612 NES 230612 2023 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in medullary cancer. Cancer, Carcinomas, Health and Medicine, Kidney, Medullary Cancer, Medullary Carcinoma, Nephrology, Oncology. [Extracted from the article]

Keywords: Weston; State:Florida; United States; North and Central America; Cancer; Carcinomas; Colon Cancer; Health and Medicine; Information Technology; Medullary Cancer; Medullary Carcinoma; Oncology EN Weston State:Florida United States North and Central America Cancer Carcinomas Colon Cancer Health and Medicine Information Technology Medullary Cancer Medullary Carcinoma Oncology 698 698 1 05/15/23 20230516 NES 230516 2023 MAY 16 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on Oncology - Colon Cancer is the subject of a report. 1,041,753 patients with colon cancer were identified of whom 2709 patients had MC and 897,902 had AC (136,597 PDA and 18,042 UDA). [Extracted from the article]

Cancer, Carcinomas, Chemotherapy, Drugs and Therapies, Health and Medicine, Kidney, Medullary Cancer, Medullary Carcinoma, Nephrology, Oncology According to news originating from Creteil, France, by NewsRx correspondents, research stated, "Renal medullary carcinoma (RMC) is a rare form of renal cell carcinoma that has a poor prognosis. Keywords: Cancer; Carcinomas; Chemotherapy; Drugs and Therapies; Health and Medicine; Kidney; Medullary Cancer; Medullary Carcinoma; Nephrology; Oncology EN Cancer Carcinomas Chemotherapy Drugs and Therapies Health and Medicine Kidney Medullary Cancer Medullary Carcinoma Nephrology Oncology 440 440 1 05/15/23 20230516 NES 230516 2023 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in medullary cancer. [Extracted from the article]

Keywords: Riverside; State:California; United States; North and Central America; Cancer; Carcinomas; Drugs and Therapies; Gastroenterology; Health and Medicine; Immunologic Agents; Immunotherapy; Medullary Cancer; Medullary Carcinoma; Monoclonal Antibodies; Oncology; Pembrolizumab Therapy; Pharmaceuticals EN Riverside State:California United States North and Central America Cancer Carcinomas Drugs and Therapies Gastroenterology Health and Medicine Immunologic Agents Immunotherapy Medullary Cancer Medullary Carcinoma Monoclonal Antibodies Oncology Pembrolizumab Therapy Pharmaceuticals 642 642 1 04/10/23 20230411 NES 230411 2023 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Data detailed on Oncology - Medullary Cancer have been presented. Keywords for this news article include: Riverside, California, United States, North and Central America, Cancer, Carcinomas, Drugs and Therapies, Gastroenterology, Health and Medicine, Immunologic Agents, Immunotherapy, Medullary Cancer, Medullary Carcinoma, Monoclonal Antibodies, Oncology, Pembrolizumab Therapy, Pharmaceuticals, University of California Riverside. [Extracted from the article]

Cancer, Carcinomas, Health and Medicine, Kidney, Kidney Cancer, Medullary Cancer, Nephrectomy, Nephrology, Oncology, Surgery, Urologic Surgical Procedures, Medullary Carcinoma Keywords: Cancer; Carcinomas; Health and Medicine; Kidney; Kidney Cancer; Medullary Cancer; Medullary Carcinoma; Nephrectomy; Nephrology; Oncology; Surgery; Urologic Surgical Procedures EN Cancer Carcinomas Health and Medicine Kidney Kidney Cancer Medullary Cancer Medullary Carcinoma Nephrectomy Nephrology Oncology Surgery Urologic Surgical Procedures 347 347 1 03/23/23 20230324 NES 230324 2023 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Research findings on medullary cancer are discussed in a new report. [Extracted from the article]

For more information on this research see: Medullary Carcinoma of the Ampulla Has Distinct Clinicopathologic Characteristics Including Common Association With Microsatellite Instability and Pd-l1 Expression. Keywords: Istanbul; Turkey; Eurasia; Cancer; Carcinomas; Health and Medicine; Medullary Cancer; Medullary Carcinoma; Microsatellite Instability; Oncology EN Istanbul Turkey Eurasia Cancer Carcinomas Health and Medicine Medullary Cancer Medullary Carcinoma Microsatellite Instability Oncology 1450 1450 1 03/23/23 20230324 NES 230324 2023 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in Oncology - Medullary Cancer. [Extracted from the article]

Reports on the determination of leukocyte infiltration using angiogenic profile of breast carcinoma in the Netherlands. Analysis of the relationship between the angiogenic profile and leukocyte infiltration of tumors, single cell suspensions of archival frozen medullary and ductal breast cancer tissues; Assessment of the profile of all tumors by quantitative real-time reverse transcription-polymerase chain reaction analysis; Indication of the capacity of vascular endothelial growth factor-C and D to decrease endothelial intercellular adhesion molecule-1 expression.

Presents a study from the Netherlands on the relationship between the angiogenic profile and leukocyte infiltration in breast cancers. Measurement of the expression of intercellular adhesion molecule-1 on the endothelial cell fraction; Performance of quantitative real-time reverse transcription-polymerase chain reaction analysis; Action of vascular endothelial growth factors.