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Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P, Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.

BK virus is a polyomavirus, which causes a ubiquitous infection with an asymptomatic course in immunocompetent individuals and is latent in the genitourinary tract. BK virus reactivation can occur with immunosuppression such as in patients after organ transplantation, which might lead to nephropathy, hemorrhagic cystitis, and has been associated with development of malignancy in the genitourinary tract and nervous system. We present a rare case of urothelial carcinoma with a prominent micropapillary component in a patient 8 years after a cardiac transplantation. Micropapillary urothelial carcinoma (MPUC) is a rare variant of bladder cancer with an aggressive course and poor prognosis. Because of its resistance to intravesical immunotherapy, radical cystectomy is the preferred treatment for nonmuscle-invasive MPUC. This case report adds to the growing body of evidence linking BK virus infection in immunosuppressed patients and the development of MPUC. This aggressive tumor should be suspected in this patient population who present with hematuria.