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Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences
- Source :
- Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021), Communications Biology
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the clinical, genomic, pathway, molecular subtype, and prognostic levels. The EAM group had increased ERG (P<br />Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.
- Subjects :
- Male
0301 basic medicine
Oncology
medicine.medical_specialty
DNA repair
QH301-705.5
Medicine (miscellaneous)
White People
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
Internal medicine
parasitic diseases
Gene expression
Cancer genomics
medicine
Humans
Biology (General)
Aged
Neoplasm Staging
Retrospective Studies
Regulation of gene expression
business.industry
Gene Expression Profiling
Prostatic Neoplasms
Genomics
Health Status Disparities
Middle Aged
Prognosis
medicine.disease
United States
Black or African American
Gene Expression Regulation, Neoplastic
MSH6
030104 developmental biology
medicine.anatomical_structure
MSH2
Immune System
030220 oncology & carcinogenesis
Tumour immunology
DNA mismatch repair
General Agricultural and Biological Sciences
business
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....25b0a9d078f07a1b4d857d121194bc63