1. Second trimester amniotic fluid endothelin-1 concentrations and subsequent development of intrauterine growth restriction
- Author
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Margarit, Lavinia, Griffiths, Anthony N., Tsapanos, Vassilios, Tsakas, Sotiris, Gumenos, Dimitios, and Decavalas, George
- Subjects
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CONCEPTION , *OBSTETRICS , *PREGNANCY , *PRENATAL diagnosis - Abstract
Abstract: Objective: The purpose of this prospective study was to record endothelin-1 (ET-1) concentrations in the second trimester amniotic fluid and compare these values in women who developed intrauterine growth restriction (IUGR) later in pregnancy with those with uneventful pregnancies. Method: Amniotic fluid was retrieved by amniocentesis from 125 women in the second trimester of pregnancy. The levels of ET1 were measured by a sensitive and specific radioimmunoassay. Results: From the 125 women included in the study 12 had pregnancies that later developed IUGR and 88 had uneventful pregnancies. The ET1 concentration was significantly higher (P <0.005) in women who later developed IUGR than in normal pregnancy (106pg/ml versus 64.7pg/ml). Conclusion: The amniotic fluid concentration of ET1 is elevated by the second trimester in women who later develop IUGR. [Copyright &y& Elsevier]
- Published
- 2007
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