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Second trimester amniotic fluid endothelin-1 concentrations and subsequent development of intrauterine growth restriction
- Source :
-
European Journal of Obstetrics & Gynecology & Reproductive Biology . Oct2007, Vol. 134 Issue 2, p192-195. 4p. - Publication Year :
- 2007
-
Abstract
- Abstract: Objective: The purpose of this prospective study was to record endothelin-1 (ET-1) concentrations in the second trimester amniotic fluid and compare these values in women who developed intrauterine growth restriction (IUGR) later in pregnancy with those with uneventful pregnancies. Method: Amniotic fluid was retrieved by amniocentesis from 125 women in the second trimester of pregnancy. The levels of ET1 were measured by a sensitive and specific radioimmunoassay. Results: From the 125 women included in the study 12 had pregnancies that later developed IUGR and 88 had uneventful pregnancies. The ET1 concentration was significantly higher (P <0.005) in women who later developed IUGR than in normal pregnancy (106pg/ml versus 64.7pg/ml). Conclusion: The amniotic fluid concentration of ET1 is elevated by the second trimester in women who later develop IUGR. [Copyright &y& Elsevier]
- Subjects :
- *CONCEPTION
*OBSTETRICS
*PREGNANCY
*PRENATAL diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 03012115
- Volume :
- 134
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Journal of Obstetrics & Gynecology & Reproductive Biology
- Publication Type :
- Academic Journal
- Accession number :
- 26842862
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2006.10.016