11 results on '"Simone, Nicole L."'
Search Results
2. A Proof-of-Concept Pilot Test of a Behavioral Intervention to Improve Adherence to Dietary Recommendations for Cancer Prevention.
- Author
-
Butryn ML, Hagerman CJ, Crane NT, Ehmann MM, Forman EM, Milliron BJ, and Simone NL
- Subjects
- Adult, Humans, Diet, Fruit, Health Education, Vegetables, Neoplasms prevention & control
- Abstract
Objectives: Prevention programs that can help adults improve the quality of their diets to reduce cancer risk are needed. This Phase IIa study prospectively tested a mHealth intervention designed to improve adherence to dietary quality guidelines for cancer prevention., Methods: All participants (N = 62) received nutrition education and a self-regulation skills curriculum, with a primary target of changing grocery shopping behavior. Using a randomized, factorial design, the study varied whether each of the following 4 components were added to the 20-week intervention: (1) location-triggered app messaging, delivered when individuals arrived at grocery stores, (2) reflections on benefits of change, delivered with extra coaching time and tailored app messages, (3) coach monitoring, in which food purchases were digitally monitored by a coach, and (4) involvement of a household member in the intervention., Results: Benchmarks were successfully met for recruitment, retention, and treatment acceptability. Across conditions, there were significant reductions in highly processed food intake ( P < .001, η
2 = .48), red and processed meat intake ( P < .001, η2 = .20), and sugar-sweetened beverage intake ( P = .008, η2 = .13) from pre-to post-treatment. Analyses examining whether each intervention component influenced change across time found that participants who received coach monitoring increased their intake of fruits, vegetables, and fiber, whereas those with no coach monitoring had less improvement ( P = .01, η2 = .14). The improvement in red and processed meat was stronger among participants with household support ON, at a marginally significant level, than those with household support OFF ( P = .056, η2 = .07)., Conclusion: This study showed feasibility, acceptability, and preliminary signals of efficacy of a remotely delivered intervention to facilitate adherence to dietary guidelines for cancer prevention and that coach monitoring and household support may be especially effective strategies. A fully powered clinical trial is warranted to test an optimized version of the intervention that includes nutrition education, self-regulation skills training, coach monitoring, and household member involvement., Trial Registration: ClinicalTrials.gov NCT04947150., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.- Published
- 2023
- Full Text
- View/download PDF
3. Perceptions of and barriers to cancer screening by the sexual and gender minority community: a glimpse into the health care disparity.
- Author
-
Lombardo J, Ko K, Shimada A, Nelson N, Wright C, Chen J, Maity A, Ruggiero ML, Richard S, Papanagnou D, Mitchell E, Leader A, and Simone NL
- Subjects
- Early Detection of Cancer, Female, Gender Identity, Healthcare Disparities, Humans, Male, Sexual Behavior, Neoplasms diagnosis, Neoplasms epidemiology, Sexual and Gender Minorities
- Abstract
Purpose: A disparity exists in cancer screening rates for the Sexual and Gender Minority (SGM) community. We sought to understand the perceptions and baseline knowledge of cancer screening among SGM community members., Methods: Survey administered via social media from June 2018 to October 2018. We asked 31 questions focused on cancer screening, human papillomavirus, emotional distress, and experience with the health care system. Those included were 18 years or older. Cancer screening attitudes and knowledge, as well as perceptions of the health care system were investigated., Results: There were 422 respondents analyzed: 24.6% identified as female, 25.5% as male, 40.1% transgender, and 9.6% as other. 65.4% of the SGM community is not certain what cancer screening to do for themselves. Only 27.3% and 55.7% knew that HPV was a risk factor associated with head and neck cancer and anal cancer, respectively. Half stated their emotional distress prevents them from getting cancer screening. It was identified that process changes in making appointments, comforts during the visit, and formal training for physicians and nurses could increase cancer screening compliance for this community. The transgender population had a trend in more gaps in knowledge of appropriate cancer screening and significant excess emotional distress., Conclusion: Gaps in cancer screening knowledge and emotional and financial distress may be responsible for the disparity of lower cancer screening rates for the SGM population and the transgender population may be most at risk. Appreciating the cancer screening concerns of the SGM population can help shape future clinical and institutional approaches to improve health care delivery., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
- Published
- 2022
- Full Text
- View/download PDF
4. Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review.
- Author
-
Zaorsky NG, Allenby T, Lin J, Rosenberg J, Simone NL, and Schmitz KH
- Subjects
- Humans, Patient Reported Outcome Measures, Male, Quality of Life, Female, Randomized Controlled Trials as Topic, Combined Modality Therapy, Prostatic Neoplasms radiotherapy, Prostatic Neoplasms pathology, Fatigue etiology, Breast Neoplasms radiotherapy, Breast Neoplasms pathology, Exercise Therapy methods, Neoplasms radiotherapy
- Abstract
Purpose: Exercise therapy (ET) is shown to improve toxicity and surrogates of survival for patients receiving chemotherapy. Current National Comprehensive Cancer Network (NCCN) guidelines lack recommendations for concurrent radiation therapy (RT) and ET. The main objective was to determine the impact of concurrent ET + RT with respect to (1) acceptability, feasibility, safety; and (2) to demonstrate how incorporating ET in cancer treatment can enhance patient-reported outcomes (PROs) and physical function-defined as strength or exercise capacity., Methods and Materials: A PICOS/PRISMA selection protocol was used to search PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Cochrane Review for prospective randomized controlled trials evaluating concurrent ET + RT, including >10 patients and with 1 or more study arms. Acceptability, feasibility, and safety rates were calculated. PROs were assessed with study-specific metrics. Physical function was defined as improvements in strength or range of motion. Statistically significant improvement was defined by P <.05., Results: Twenty-six of 693 screened studies including 1563 patients (831 receiving exercise, 732 controls) with localized breast cancer (67.1% of patients), prostate cancer (27.4%), head and neck cancers (2.8%), and spinal metastases (2.8%) were assessed. Objective 1: Among 3385 patients approached for ET, 1864 (55.1%) accepted the treatment; of those, 1563 patients (83.9%) completed the trials. Objective 2: Statistical improvements were noted in these PROs: quality of life (14 of 15 studies), fatigue (12 of 16 studies), mood/depression (9 of 13), and anxiety (6 of 7). Physical function improved statically in 16 of 16 studies., Conclusions: Combination ET + RT is safe and well-tolerated with improvements in PROs and physical function. Additional studies are needed in patients with metastatic cancers to assess survival and to compare effectiveness of different exercise regimens., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
5. The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.
- Author
-
Xavier JB, Young VB, Skufca J, Ginty F, Testerman T, Pearson AT, Macklin P, Mitchell A, Shmulevich I, Xie L, Caporaso JG, Crandall KA, Simone NL, Godoy-Vitorino F, Griffin TJ, Whiteson KL, Gustafson HH, Slade DJ, Schmidt TM, Walther-Antonio MRS, Korem T, Webb-Robertson BM, Styczynski MP, Johnson WE, Jobin C, Ridlon JM, Koh AY, Yu M, Kelly L, and Wargo JA
- Subjects
- Analgesics, Opioid therapeutic use, Animals, Bacteria metabolism, Central Nervous System physiology, Drug Synergism, Environmental Microbiology, Gastritis microbiology, Gastrointestinal Microbiome, Helicobacter Infections complications, Host-Pathogen Interactions, Humans, Immunotherapy, Mice, Neoplasms etiology, Neoplasms therapy, Neoplasms virology, Oncogenic Viruses pathogenicity, Probiotics, Stomach Neoplasms etiology, Stomach Neoplasms microbiology, Symbiosis, Tumor Virus Infections, Microbiota drug effects, Microbiota radiation effects, Neoplasms microbiology
- Abstract
The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach., (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
6. Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet.
- Author
-
Wright C and Simone NL
- Subjects
- Adaptive Immunity, Adiposity, Animals, Combined Modality Therapy, Diet, Reducing, Endocrine System Diseases immunology, Endocrine System Diseases pathology, Endocrine System Diseases physiopathology, Humans, Immune System Diseases immunology, Immune System Diseases pathology, Immune System Diseases physiopathology, Immunity, Innate, Inflammation Mediators metabolism, Intra-Abdominal Fat immunology, Intra-Abdominal Fat metabolism, Intra-Abdominal Fat pathology, Neoplasms etiology, Neoplasms immunology, Neoplasms pathology, Obesity immunology, Obesity pathology, Obesity physiopathology, Tumor Burden, Carcinogenesis, Diet, Ketogenic, Endocrine System Diseases therapy, Exercise, Immune System Diseases therapy, Neoplasms therapy, Obesity therapy
- Abstract
Purpose of Review: This article reviews the impact the obese state has on malignancy through inflammation and immune dysregulation using recent excerpts from the medical literature., Recent Findings: The obese state creates a proinflammatory endocrinologic milieu altering cellular signaling between adipocytes, immunologic cells, and epithelial cells, leading to the over-activation of adipose tissue macrophages and the upregulation of compounds associated with carcinogenesis. Obesity correlates with a deficiency in numerous immunologic cells, including dendritic cells, natural killer cells, and T cells. In part, this can be attributed to a recent finding of leptin receptor expression on these immune cells and the upregulation of leptin signaling in the obese state. A number of clinical trials have demonstrated the feasibility of a high-fat, low-carbohydrate diet as an adjuvant treatment for cancer, and current trials are investigating the impact of this intervention on disease outcomes. In preclinical trials, a ketogenic diet has been shown to impede tumor growth in a variety of cancers through anti-angiogenic, anti-inflammatory, and proapoptotic mechanisms., Summary: Obesity is becoming more prevalent and its link to cancer is clearly established providing a rationale for the implementation of dietary interventions as an adjuvant therapeutic strategy for malignancy.
- Published
- 2016
- Full Text
- View/download PDF
7. What benefits could caloric restriction bring to cancer patients?
- Author
-
Dan TD, Wright CM, and Simone NL
- Subjects
- Humans, Neoplasms physiopathology, Caloric Restriction, Neoplasms diet therapy
- Published
- 2014
- Full Text
- View/download PDF
8. Selectively starving cancer cells through dietary manipulation: methods and clinical implications.
- Author
-
Simone BA, Champ CE, Rosenberg AL, Berger AC, Monti DA, Dicker AP, and Simone NL
- Subjects
- Animals, Caloric Restriction adverse effects, Diet, Reducing, Fasting, Humans, Ketosis, Neoplasms complications, Obesity diet therapy, Obesity metabolism, Obesity physiopathology, Patient Compliance, Neoplasms diet therapy, Neoplasms metabolism
- Abstract
As the link between obesity and metabolic syndrome and cancer becomes clearer, the need to determine the optimal way to incorporate dietary manipulation in the treatment of cancer patients becomes increasingly important. Metabolic-based therapies, such as caloric restriction, intermittent fasting and a ketogenic diet, have the ability to decrease the incidence of spontaneous tumors and slow the growth of primary tumors, and may have an effect on distant metastases in animal models. Despite the abundance of preclinical data demonstrating the benefit of dietary modification for cancer, to date there are few clinical trials targeting diet as an intervention for cancer patients. We hypothesize that this may be due, in part, to the fact that several different types of diet modification exist with no clear recommendations regarding the optimal method. This article will delineate three commonly used methods of dietary manipulation to assess the potential of each as a regimen for cancer therapy.
- Published
- 2013
- Full Text
- View/download PDF
9. Nutrient restriction and radiation therapy for cancer treatment: when less is more.
- Author
-
Champ CE, Baserga R, Mishra MV, Jin L, Sotgia F, Lisanti MP, Pestell RG, Dicker AP, and Simone NL
- Subjects
- Clinical Trials as Topic, Eating physiology, Energy Intake physiology, Humans, Longevity physiology, Neoplasms metabolism, Neoplasms physiopathology, Caloric Restriction methods, Metabolic Networks and Pathways genetics, Metabolic Networks and Pathways physiology, Neoplasms diet therapy, Neoplasms radiotherapy
- Abstract
Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control.
- Published
- 2013
- Full Text
- View/download PDF
10. In reply.
- Author
-
Champ CE and Simone NL
- Subjects
- Humans, Caloric Restriction methods, Metabolic Networks and Pathways, Neoplasms diet therapy, Neoplasms radiotherapy
- Published
- 2013
- Full Text
- View/download PDF
11. Dietary recommendations during and after cancer treatment: consistently inconsistent?
- Author
-
Champ CE, Mishra MV, Showalter TN, Ohri N, Dicker AP, and Simone NL
- Subjects
- Body Weight, Consensus, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Energy Intake, Feeding Behavior, Humans, Information Services standards, Meals, Nutrition Policy, Practice Guidelines as Topic, Diet, Neoplasms therapy
- Abstract
Recent data reveals that dietary factors may influence outcomes in patients undergoing cancer treatment. However, patient-centered information on dietary recommendations is limited. In this study, we assessed dietary recommendations for cancer patients during treatment and survivorship by evaluating the websites of all National Comprehensive Cancer Network (NCCN) member institutions. NCCN members were identified on www.nccn.org , and individual websites were reviewed for nutritional content. Recommendations were categorized by meal frequency, diet type, macronutrient content, and other specific recommendations. Twenty-one NCCN member institutions were identified. Only 4 sites (19%) provided nutritional guidelines. Half promoted a low-fat, high-carbohydrate diet recommending 5:1 and 7:1 ratios of carbohydrate to fat food types, and half promoted weight maintenance during treatment, endorsing a 1:1 ratio of carbohydrate to fat. One third of all NCCN sites (n = 7) had links to 9 external websites. Four external sites provided nutrition guidelines: half favored a low-fat, high-carbohydrate diet, and half favored high-caloric intake to maintain weight. Consistent online dietary recommendations are lacking for patients during and after cancer treatment. Given the lack of consensus on dietary recommendations, future research is warranted to develop evidenced-based guidelines that can be used by oncologists and patients alike.
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.