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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Mar; Vol. 6 (3), pp. 192-204. Date of Electronic Publication: 2020 Feb 07. - Publication Year :
- 2020
-
Abstract
- The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach.<br /> (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Analgesics, Opioid therapeutic use
Animals
Bacteria metabolism
Central Nervous System physiology
Drug Synergism
Environmental Microbiology
Gastritis microbiology
Gastrointestinal Microbiome
Helicobacter Infections complications
Host-Pathogen Interactions
Humans
Immunotherapy
Mice
Neoplasms etiology
Neoplasms therapy
Neoplasms virology
Oncogenic Viruses pathogenicity
Probiotics
Stomach Neoplasms etiology
Stomach Neoplasms microbiology
Symbiosis
Tumor Virus Infections
Microbiota drug effects
Microbiota radiation effects
Neoplasms microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32101723
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.01.004