1. Construction and synergistic anti-tumor study of a tumor microenvironment-based multifunctional nano-drug delivery system.
- Author
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Liu B, Zheng Q, Shi X, Shen J, Li R, and Zhou J
- Subjects
- Animals, Humans, Mice, Cell Line, Tumor, Photochemotherapy, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Glucuronic Acid chemistry, Hexuronic Acids chemistry, Drug Delivery Systems, Drug Liberation, Porosity, Photosensitizing Agents chemistry, Photosensitizing Agents pharmacology, Photosensitizing Agents therapeutic use, Drug Synergism, Nanoparticle Drug Delivery System chemistry, Silicon Dioxide chemistry, Tumor Microenvironment drug effects, Alginates chemistry, Tirapazamine chemistry, Tirapazamine pharmacology, Nanoparticles chemistry, Perylene analogs & derivatives, Perylene chemistry, Perylene pharmacology, Anthracenes chemistry
- Abstract
To solve the problems existing in the clinical application of hypericin (Hyp) and tirapazamine (TPZ), a nano-drug delivery system with synergistic anti-tumor functions was constructed using mesoporous silica nanoparticles (MSN) and sodium alginate (SA). The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the in vitro and in vivo experiments, Hyp released from MSN killed tumor cells through photodynamic therapy (PDT). The degree of hypoxia in the tumor tissue site was exacerbated, enabling TPZ to fully exert its anti-tumor activity. Our studies suggested that the synergistic effects between the components of the nano-drug delivery system significantly improve the anti-tumor properties of Hyp and TPZ., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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