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Near-infrared photoactivatable three-in-one nanoagents to aggravate hypoxia and enable amplified photo-chemotherapy.
- Source :
-
Biomaterials advances [Biomater Adv] 2024 Oct; Vol. 163, pp. 213962. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
-
Abstract
- Solid tumors create a hypoxic microenvironment and this character can be utilized for cancer therapy, but the hypoxia levels are insufficient to achieve satisfactory therapeutic benefits. Some tactics have been used to improve hypoxia, which however will cause side effects due to the uncontrolled drug release. We herein report near-infrared (NIR) photoactivatable three-in-one nanoagents (PCT) to aggravate tumor hypoxia and enable amplified photo-combinational chemotherapy. PCT are formed based on a thermal-responsive liposome nanoparticle containing three therapeutic agents: a hypoxia responsive prodrug tirapazamine (TPZ) for chemotherapy, a vascular targeting agent combretastatin A-4 (CA4) for vascular disturbance and a semiconducting polymer for both photodynamic therapy (PDT) and photothermal therapy (PTT). With NIR laser irradiation, PCT generate heat for PTT and destructing thermal-responsive liposomes to achieve activatable releases of TPZ and CA4. Moreover, PCT produce singlet oxygen ( <superscript>1</superscript> O <subscript>2</subscript> ) for PDT via consuming tumor oxygen. CA4 can disturb the blood vessels in tumor microenvironment to aggravate the hypoxic microenvironment, which results in the activation of TPZ for amplified chemotherapy. PCT thus enable PTT, PDT and hypoxia-amplified chemotherapy to afford a high therapeutic efficacy to almost absolutely eradicate subcutaneous 4 T1 tumors and effectively inhibit tumor metastases in lung and liver. This work presents an activatable three-in-one therapeutic nanoplatform with remotely controllable and efficient therapeutic actions to treat cancer.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Humans
Mice
Tumor Microenvironment drug effects
Cell Line, Tumor
Photothermal Therapy methods
Stilbenes pharmacology
Stilbenes therapeutic use
Stilbenes chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Prodrugs pharmacology
Prodrugs chemistry
Prodrugs therapeutic use
Photosensitizing Agents therapeutic use
Photosensitizing Agents pharmacology
Photosensitizing Agents chemistry
Tumor Hypoxia drug effects
Photochemotherapy methods
Tirapazamine pharmacology
Tirapazamine chemistry
Tirapazamine therapeutic use
Nanoparticles chemistry
Nanoparticles therapeutic use
Infrared Rays
Liposomes
Subjects
Details
- Language :
- English
- ISSN :
- 2772-9508
- Volume :
- 163
- Database :
- MEDLINE
- Journal :
- Biomaterials advances
- Publication Type :
- Academic Journal
- Accession number :
- 39032435
- Full Text :
- https://doi.org/10.1016/j.bioadv.2024.213962