1. Engineering multifunctional bactericidal nanofibers for abdominal hernia repair.
- Author
-
Afewerki S, Bassous N, Harb SV, Corat MAF, Maharjan S, Ruiz-Esparza GU, de Paula MMM, Webster TJ, Tim CR, Viana BC, Wang D, Wang X, Marciano FR, and Lobo AO
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Disease Models, Animal, Gelatin chemistry, Hernia, Abdominal pathology, Methacrylates chemistry, Mice, NIH 3T3 Cells, Nanomedicine, Polyesters chemistry, Rats, Surgical Wound Infection microbiology, Wound Healing drug effects, Anti-Bacterial Agents pharmacology, Biocompatible Materials, Gelatin pharmacology, Hernia, Abdominal surgery, Herniorrhaphy instrumentation, Methacrylates pharmacology, Nanofibers, Polyesters pharmacology, Surgical Wound Infection prevention & control, Tissue Scaffolds
- Abstract
The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.
- Published
- 2021
- Full Text
- View/download PDF