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Engineering multifunctional bactericidal nanofibers for abdominal hernia repair.
- Source :
-
Communications biology [Commun Biol] 2021 Feb 19; Vol. 4 (1), pp. 233. Date of Electronic Publication: 2021 Feb 19. - Publication Year :
- 2021
-
Abstract
- The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.
- Subjects :
- Animals
Anti-Bacterial Agents chemistry
Disease Models, Animal
Gelatin chemistry
Hernia, Abdominal pathology
Methacrylates chemistry
Mice
NIH 3T3 Cells
Nanomedicine
Polyesters chemistry
Rats
Surgical Wound Infection microbiology
Wound Healing drug effects
Anti-Bacterial Agents pharmacology
Biocompatible Materials
Gelatin pharmacology
Hernia, Abdominal surgery
Herniorrhaphy instrumentation
Methacrylates pharmacology
Nanofibers
Polyesters pharmacology
Surgical Wound Infection prevention & control
Tissue Scaffolds
Subjects
Details
- Language :
- English
- ISSN :
- 2399-3642
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Communications biology
- Publication Type :
- Academic Journal
- Accession number :
- 33608611
- Full Text :
- https://doi.org/10.1038/s42003-021-01758-2