1. Passive and active target delivery of drugs to ischemic myocardium.
- Author
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Galagudza MM, Korolev DV, Sonin DL, Alexandrov IV, Minasian SM, Postnov VN, Kirpicheva EB, Papayan GV, and Uskov IS
- Subjects
- Animals, Blood Pressure drug effects, Drug Carriers toxicity, Fluorescein pharmacokinetics, Fluorescent Dyes pharmacokinetics, Heart Rate drug effects, Materials Testing, Myocardium metabolism, Nanoparticles, Particle Size, Rats, Rats, Wistar, Silicon Dioxide toxicity, Tissue Distribution, Drug Carriers pharmacokinetics, Myocardial Ischemia drug therapy, Silicon Dioxide pharmacokinetics
- Abstract
Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia-reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.
- Published
- 2011
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