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Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2010 Apr 07; Vol. 5, pp. 231-7. Date of Electronic Publication: 2010 Apr 07. - Publication Year :
- 2010
-
Abstract
- The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their characterization and surface modification. The acute hemodynamic effects of nanoparticle formulation as well as nanoparticle biodistribution were studied in male Wistar rats. Carbon and silica nanoparticles are nontoxic materials that can be used as carriers for heart-targeted drug delivery. Concepts of passive and active targeting can be applied to the development of targeted drug delivery to the ischemic myocardial cells. Provided that ischemic heart-targeted drug delivery can be proved to be safe and efficient, the results of this research may contribute to the development of new technologies in the pharmaceutical industry.
- Subjects :
- Animals
Cardiotonic Agents chemistry
Drug Carriers chemical synthesis
Drug Carriers pharmacokinetics
Male
Nanoparticles chemistry
Organ Specificity
Rats
Rats, Wistar
Tissue Distribution
Treatment Outcome
Cardiotonic Agents administration & dosage
Cardiotonic Agents pharmacokinetics
Drug Carriers administration & dosage
Myocardial Ischemia drug therapy
Myocardial Ischemia metabolism
Nanoparticles administration & dosage
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 20463939
- Full Text :
- https://doi.org/10.2147/ijn.s8719