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The MPN driver mutation, JAK2 exon 12, is rare in MPN and has been exclusively found in polycythaemia vera (PV) (Scott [6]), with no reports of this mutation in MDS/MPN-RS-T to date. We would like to emphasize the importance of analysing JAK2 exon 12 mutation in patients with suspected MDS/MPN-RS-T, but who are negative for JAK2 V617F, CALR exon 9 and MPL W515 mutations. In summary, we identified a patient with MDS/MPN-RS-T harboring SF3B1 and JAK2 exon 12 mutations. Bone marrow morphologies of the patient harboring JAK2 exon 12 mutation, representing features associated with MDS/MPN-RS-T.Figure S3. [Extracted from the article]

The article offers information on the erythroid hypoplasia or aplasia which is a haematological condition observed in acquired pure red cell aplasia (PRCA) and aplastic anaemia. It discusses the pathogenic mechanisms of erythroid hypoplasia have not been fully elucidated, although T-lymphocyte-mediated inhibition of erythropoiesis which is considered as the most accurate mechanism of pathogenesis.