Expansion of CD8+/perforin+ T-cells predicts response to ciclosporin A therapy in patients with erythroid hypoplasia/aplasia.

The article offers information on the erythroid hypoplasia or aplasia which is a haematological condition observed in acquired pure red cell aplasia (PRCA) and aplastic anaemia. It discusses the pathogenic mechanisms of erythroid hypoplasia have not been fully elucidated, although T-lymphocyte-mediated inhibition of erythropoiesis which is considered as the most accurate mechanism of pathogenesis.