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5 results on '"Ecoanalytica"'

1. Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.

Author

McKinnon S, Guatelli S, Incerti S, Ivanchenko V, Konstantinov K, Corde S, Lerch M, Tehei M, and Rosenfeld A

Subjects
Cerium chemistry, Cerium pharmacology, Gold chemistry, Humans, Male, Metal Nanoparticles chemistry, Prostatic Neoplasms radiotherapy, Radiotherapy Dosage, Tantalum chemistry, Tantalum pharmacology, Monte Carlo Method, Nanoparticles, Oxides chemistry, Oxides pharmacology, Proton Therapy methods, Radiation Dosage
Abstract

Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta 2 O 5 and CeO 2 , in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared against gold NPs. The energy deposition on a nanoscale around a single nanoparticle of 100nm diameter is investigated using the Geant4-DNA extension to model particle interactions in the water medium. Enhancement of energy deposition in nano-sized shells of water, local to the NP boundary, ranging between 14% and 27% was observed for proton energies of 5MeV and 50MeV, depending on the NP material. Enhancement of electron production and energy deposition can be correlated to the direct DNA damage mechanism if the NP is in close proximity to the nucleus., (Copyright © 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)

Published
2016
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2. Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit.

Author

Bernal MA, Bordage MC, Brown JMC, Davídková M, Delage E, El Bitar Z, Enger SA, Francis Z, Guatelli S, Ivanchenko VN, Karamitros M, Kyriakou I, Maigne L, Meylan S, Murakami K, Okada S, Payno H, Perrot Y, Petrovic I, Pham QT, Ristic-Fira A, Sasaki T, Štěpán V, Tran HN, Villagrasa C, and Incerti S

Subjects
Chemical Phenomena, Humans, DNA chemistry, Models, Molecular, Monte Carlo Method, Water chemistry
Abstract

Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described., (Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.)

Published
2015
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3. Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

Author

K. Murakami, Susanna Guatelli, Vladimir Ivanchenko, Takashi Sasaki, Jeremy M. C. Brown, Ioanna Kyriakou, E. Delage, Mario A. Bernal, H. Payno, Marie-Claude Bordage, Ivan Petrović, Sylvain Meylan, Q.T. Pham, Aleksandra Ristić-Fira, Shirin A. Enger, Yann Perrot, Ziad Francis, Václav Štěpán, Shogo Okada, Z. El Bitar, M. Karamitros, Carmen Villagrasa, Lydia Maigne, Sebastien Incerti, Marie Davídková, H.N. Tran, Instituto de Fisica 'Gleb Wataghin', Universidade Estadual de Campinas (UNICAMP), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), School of Mathematics and Physics [Belfast], Queen's University [Belfast] (QUB), School of Physics and Astronomy [Clayton], Monash University [Clayton], Department of Radiation Dosimetry, Nuclear Physics Institute of the AS CR, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Medical Physics Unit, Department of Oncology, McGill University = Université McGill [Montréal, Canada], Department of Physics, Faculty of Sciences, Université Saint-Joseph de Beyrouth (USJ), Centre for Medical Radiation Physics, University of Wollongong [Australia], Geant4 Associates International Ltd, Ecoanalytica, Notre Dame Radiation Laboratory, University of Notre Dame [Indiana] (UND), Medical Physics Laboratory, Medical School University of Ioannina, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), KEK (High energy accelerator research organization), Vinča Institute of Nuclear Sciences, University of Belgrade [Belgrade], Division of Nuclear Physics, Tong Duc Thang University, Faculty of Applied Sciences, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Nuclear Physics Institute of the ASCR, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), McGill University, University of Wollongong, High Energy Accelerator Research Organization (KEK), University of Tsukuba, Universidade Estadual de Campinas = University of Campinas (UNICAMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Ioannina, and Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Models, Molecular, Chemical process, Ionizing radiation, Chemical Phenomena, Stochastic modelling, Liquid water, Monte Carlo method, Biophysics, General Physics and Astronomy, Track (rail transport), Radiolysis, Humans, Radiology, Nuclear Medicine and imaging, Monte Carlo, Simulation, Physics, Structure (mathematical logic), Physical model, Geant4-DNA, Water, Radiobiology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, General Medicine, Extension (predicate logic), [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Systems engineering, Monte Carlo Method
Abstract

International audience; Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described.

Published
2015
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4. Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study

Author

Incerti, Sebastien, Psaltaki, Maria G., Gillet, Pierre, Barberet, Ph., Bardies, M., Bernal, Mario A., Bordage, Marie Claude, Breton, Vincent, Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Francis, Ziad, Guatelli, Susanna, Ivanchenko, A., Ivanchenko, Vladimir, Karamitros, Mathieu, Lee, Sebyeong, Maigne, Lydia, Meylan, Sylvain, Murakami, Kouichi, Nieminen, Petteri H., Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Santin, Giovanni, Sasaki, Takashi, Seznec, Herve, Shin, Jae-ik, Stepan, Vaclav, Tran, Ngoc Hoang, Villagrasa, Carmen, Geant4-DNA Collaboration, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), National Technical University of Athens [Athens] (NTUA), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Fisica 'Gleb Wataghin' (INSTITUTO DE FISICA 'GLEB WATAGHIN'), Universidade Estadual de Campinas (UNICAMP), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Radiation Dosimetry, Nuclear Physics Institute of the AS CR, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Faculty of Sciences, Université Saint-Joseph de Beyrouth (USJ), Centre for Medical Radiation Physics, University of Wollongong [Australia], Geant4 Associates International (G4AI), Ecoanalytica, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Proton Therapy Center, National Cancer Center Korea, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), KEK (High energy accelerator research organization), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Vinča Institute of Nuclear Sciences, University of Belgrade [Belgrade], Ton Duc Thang University [Hô-Chi-Minh-City], Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), and Agence Spatiale Européenne = European Space Agency (ESA)

Subjects
Nuclear and High Energy Physics, Work (thermodynamics), Radiation transport, Physics::Medical Physics, Reference data (financial markets), Monte Carlo method, Ion, Deposition (phase transition), Statistical physics, Instrumentation, Monte Carlo, Physics, Energy depositions, [PHYS]Physics [physics], Geant4-DNA, Ion track, Geant4 dnas, Monte Carlo methods, Liquids, DNA, Analytical calculation, Monte- carlo simulations, Charged particle, Computational physics, Comparative studies, Liquid water, Dose, Dynamic Monte Carlo method
Abstract

International audience; An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at the sub-cellular scale. The work presented in this paper is part of the on-going benchmarking of the "Geant4-DNA" physics processes and models, which are available in the Geant4 Monte Carlo simulation toolkit for the low energy transport of particles in liquid water. We present for the first time radial dose distributions of incident ion tracks simulated with "Geant4-DNA". Simulation results are compared to other results available in the literature, obtained from analytical calculations, step-by-step Monte Carlo simulations and measurements. They show a reasonable agreement with reference data. © 2014 Elsevier B.V. All rights reserved.

Published
2014
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5. Dose point kernels in liquid water: An intra-comparison between GEANT4-DNA and a variety of Monte Carlo codes

Author

Vladimir Ivanchenko, Michel Fromm, L. Campos, B. Mascialino, Marie-Claude Bordage, Sebastien Incerti, Christophe Champion, J.-E. Groetz, Yann Perrot, H.N. Tran, R. Delorme, Manuel Bardiès, Mario A. Bernal, Ziad Francis, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Modélisation et Simulation de Systèmes (LM2S), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, LAboratoire PLasma et Conversion d'Energie (LAPLACE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Saint-Joseph de Beyrouth (USJ), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), ANR-09-BLAN-0135,Geant4-DNA,Modélisation des dommages à l'ADN induits par les rayonnements ionisants avec l'outil Monte Carlo Geant4 et validation expérimentale(2009), Interface Physique et Chimie pour le Vivant ( IPCV ), Centre d'Etudes Nucléaires de Bordeaux Gradignan ( CENBG ), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Corpusculaire - Clermont-Ferrand ( LPC ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Information, Modèles, Apprentissage [Gif-sur-Yvette], Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire Plasma et Conversion d'Energie [Toulouse] ( LAPLACE ), Institut National Polytechnique [Toulouse] ( INP ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Cancérologie de Toulouse ( CRCT ), Université Paul Sabatier - Toulouse 3 ( UPS ) -CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of medical radiation physics, Stockholm University, Eco-Analytica Laboratory, North-West University [South Aftrica] ( NWU ), Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas ( UNICAMP ), Université Saint-Joseph de Beyrouth ( USJ ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Departamento de Física, Universidade Federal de Sergipe, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Ecoanalytica, Instituto de Fisica 'Gleb Wataghin' (INSTITUTO DE FISICA 'GLEB WATAGHIN'), Universidade Estadual de Campinas (UNICAMP), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Universidade Federal de Sergipe, Departamento de Física, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Laboratoire Chrono-environnement (UMR 6249) (LCE), Fromm, Michel, and Blanc - Modélisation des dommages à l'ADN induits par les rayonnements ionisants avec l'outil Monte Carlo Geant4 et validation expérimentale - - Geant4-DNA2009 - ANR-09-BLAN-0135 - Blanc - VALID

Subjects
[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], Monte Carlo method, Physics::Medical Physics, Elementary particle, Context (language use), Electron, PENELOPE, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], modelling, particle transport, Dosimetry, Point (geometry), Statistical physics, Monte Carlo, MCNPX, radiotherapy, Physics, energy-matter interaction, Monte Carlo codes, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [STAT.ME] Statistics [stat]/Methodology [stat.ME], Radiation, dosimetry, simulation, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Charged particle, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Liquid water, Dose point kernel, [ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistry, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], GEANT4-DNA, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, ionizing radiation, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Lepton
Abstract

International audience; Modeling the radio-induced effects in biological medium still requires accurate physics models to describe the interactions induced by all the charged particles present in the irradiated medium in detail. These interactions include inelastic as well as elastic processes. To check the accuracy of the very low energy models recently implemented into the GEANT4 toolkit for modeling the electron slowing-down in liquid water, the simulation of electron dose point kernels remains the preferential test. In this context, we here report normalized radial dose profiles, for mono-energetic point sources, computed in liquid water by using the very low energy "GEANT4-DNA" physics processes available in the GEANT4 toolkit. In the present study, we report an extensive intra-comparison of profiles obtained by a large selection of existing and well-documented Monte-Carlo codes, namely, EGSnrc, PENELOPE, CPA100, FLUKA and MCNPX.

Published
2014
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