1. Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction.
- Author
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Tobón Zapata, Gloria Elena, Martínez Carmona, Dina Marcela, Alberto Echeverría, Gustavo, and Piro, Oscar Enrique
- Subjects
NORFLOXACIN ,X-ray powder diffraction ,MOLECULAR structure ,X-ray diffraction ,COPPER compounds ,COPPER powder ,ATOMS ,ABSORPTION spectra - Abstract
The crystal structures of bis[1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-ium-4-yl)-1,4- dihydroquinoline-3-carboxylato]copper(II) sulfate heptahydrate, [Cu(C
16 H18 FN3 O3 )2 ]S O4 .7H2 O or [Cu(nor)2 ]SO4 .7H2 O (nor is norfloxacin), and bis{1-[2- (ethylsulfonyl)ethyl]-2-methyl-5-nitroimide}dinitratocopper(II), [Cu(NO3 )2- (C8 H13 N3 O4 S)2 ] or [Cu(NO3 )2 (tnz)2] (tnz is tinidazole), were solved by X-ray diffraction. Both complexes crystallize in the space group P21/c, with Z = 4 (for nor) and Z = 2 (for ntz) molecules per unit cell. In [Cu(nor)2 ]SO4 .7H2 O, the CuII ion is at the centre of a square-planar environment, trans coordinated to two independent norfloxacin molecules in the zwitterionic form acting as bidentate ligands through one of the carboxyl (cbx) and the carbonyl (cb) O atoms. The solid is further stabilized by an extensive network of N--H. . .O(sulfate), N--H. . .O(cbx), N--H. . .OW, OW--H. . .O(sulfate) and OW--H. . .OW hydrogen bonds. The [Cu(NO3 )2 (tnz)2 ] complex is centrosymmetric, with the CuII ion in a square planar environment, coordinated to a tinidazole molecule acting as a monodentate ligand through its imidazole N atom and to one nitrate O atom. The vibrational FT-IR absorption spectra and thermal behaviour of the complexes were also studied and are briefly discussed based on the crystal structures. [ABSTRACT FROM AUTHOR]- Published
- 2022
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