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Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction.
- Source :
- Acta Crystallographica Section B: Structural Science, Crystal Engineering & Materials; Jun2022, Vol. 78 Issue 3, Part 1, p490-498, 9p
- Publication Year :
- 2022
-
Abstract
- The crystal structures of bis[1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-ium-4-yl)-1,4- dihydroquinoline-3-carboxylato]copper(II) sulfate heptahydrate, [Cu(C<subscript>16</subscript>H<subscript>18</subscript>FN<subscript>3</subscript>O<subscript>3</subscript>) <subscript>2</subscript>]<subscript>S</subscript>O<subscript>4</subscript>.7H<subscript>2</subscript>O or [Cu(nor)<subscript>2</subscript>]SO<subscript>4</subscript>.7H<subscript>2</subscript>O (nor is norfloxacin), and bis{1-[2- (ethylsulfonyl)ethyl]-2-methyl-5-nitroimide}dinitratocopper(II), [Cu(NO<subscript>3</subscript>)2- (C<subscript>8</subscript>H<subscript>13</subscript>N<subscript>3</subscript>O<subscript>4</subscript>S)<subscript>2</subscript>] or [Cu(NO<subscript>3</subscript><subscript>)2</subscript>(tnz)2] (tnz is tinidazole), were solved by X-ray diffraction. Both complexes crystallize in the space group P21/c, with Z = 4 (for nor) and Z = 2 (for ntz) molecules per unit cell. In [Cu(nor)<subscript>2</subscript>]SO<subscript>4</subscript>.7H<subscript>2</subscript>O, the CuII ion is at the centre of a square-planar environment, trans coordinated to two independent norfloxacin molecules in the zwitterionic form acting as bidentate ligands through one of the carboxyl (cbx) and the carbonyl (cb) O atoms. The solid is further stabilized by an extensive network of N--H. . .O(sulfate), N--H. . .O(cbx), N--H. . .OW, OW--H. . .O(sulfate) and OW--H. . .OW hydrogen bonds. The [Cu(NO<subscript>3</subscript>)<subscript>2</subscript>(tnz)<subscript>2</subscript>] complex is centrosymmetric, with the CuII ion in a square planar environment, coordinated to a tinidazole molecule acting as a monodentate ligand through its imidazole N atom and to one nitrate O atom. The vibrational FT-IR absorption spectra and thermal behaviour of the complexes were also studied and are briefly discussed based on the crystal structures. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20525192
- Volume :
- 78
- Issue :
- 3, Part 1
- Database :
- Complementary Index
- Journal :
- Acta Crystallographica Section B: Structural Science, Crystal Engineering & Materials
- Publication Type :
- Academic Journal
- Accession number :
- 158129410
- Full Text :
- https://doi.org/10.1107/S2052520622003766