13 results on '"Lin, Wenxin"'
Search Results
2. A pH‐responsive Zr‐based metal organic framework PCN‐777 as a potential oral drug carrier.
- Author
-
He, Qing, Lu, Wenwen, Jiang, Xiaoying, Han, Yuanbo, Yu, Hongliu, Zhao, Hong, Guan, Xinghua, and Lin, Wenxin
- Subjects
METAL-organic frameworks ,ORAL medication ,DRUG carriers ,ANTI-inflammatory agents ,TRICHLOROPHENOL - Abstract
A Zr‐based metal‐organic framework PCN‐777 with good biocompatibility was synthesized by solvothermal method using 2,4,6‐Tris(4‐Carboxyphenyl)‐1,3,5‐Triazine and ZrOCl2 ⋅ 8H2O as raw materials. Its structure was identified and the results showed that it had good crystallinity. Then the anti‐inflammatory drug ibuprofen sodium was loaded into PCN‐777 to establish an IBUNa@PCN‐777 compound and the maximum loading capacity was tested. When the mass ratio of IBUNa to PCN‐777 was 4 : 1, the loading of IBUNa in IBUNa@PCN‐777 reached the maximum value 72.53 wt %. Biocompatibility investigation indicated PCN‐777 and IBUNa@PCN‐777 had good biocompatibility. Moreover, the drug release behavior of IBUNa@PCN‐777 testified the drug release at pH 7.4(>80 %) was greater than that at pH 2.0(<20 %). indicated that IBUNa@PCN‐777 had good pH response in simulated digestive environments. The above results demonstrated that PCN‐777 had potential application prospects as an oral drug carrier. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. A Novel Zn (II)‐Based Metal‐Organic Framework as a Highly Selective and Sensitive Luminescent Sensor for the Detection of Nitrofuran Antibiotics.
- Author
-
Lu, Mengting, Xiao, Xiaoyan, Yu, Shijiang, Lin, Wenxin, and Yang, Yu
- Subjects
METAL-organic frameworks ,ANTIBIOTICS ,DETECTORS ,MODERN society ,WASTE recycling ,DETECTION limit - Abstract
The abuse of antibiotics has led to serious environmental and health problems in the modern society. The detection on antibiotics with high selectivity and sensitivity is urgently needed. In this work, we synthesized a new zinc‐based metal‐organic frameworks, {[Zn3(TCPPDA)4] ⋅ 8DMF ⋅ 2H2O}n, namely ZJU‐126. The as‐obtained ZJU‐126 has demonstrated its usage as a platform of luminescent sensor for nitrofurazone (NZF) and nitrofurantoin (NFT) with strong quenching constants and low detection limits of 5.8×104 M−1 and 0.56 μM for NZF as well as 4×104 M−1 and 0.82 μM for NFT, respectively. Particularly, ZJU‐126 exhibits excellent selectivity, anti‐interference and recyclability. The possible mechanism involved has also been discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. A Zr‐Based MOF with N‐heterocycle and its pH‐controlled drug release behavior.
- Author
-
He, Qing, Shen, Jie, Guan, Xinghua, Han, Yuanbo, Jiang, Xiaoying, Shen, Xiaoan, Huang, Xiajuan, Chen, Yufeng, Lei, Chen, Xiao, Xiaoyan, and Lin, Wenxin
- Subjects
DRUG carriers ,METAL-organic frameworks ,ORAL medication ,ANTI-inflammatory agents ,DICLOFENAC ,DRUGS - Abstract
A Zr‐based metal‐organic framework was synthesized by solvothermal method. It was designated as UiO‐67(bpy) since its structure matched well with UiO‐67 according to the X‐ray diffraction results. The cytotoxicity assay of UiO‐67(bpy) was measured and it revealed that UiO‐67(bpy) had excellent biocompatibility. UiO‐67(bpy) was used to load anti‐inflammatory drugs, and the loading capacity of diclofenac sodium (DS) of UiO‐67(bpy) reached 30.08 wt %. Furthermore, the DS@UiO‐67(bpy) exhibited a pH‐controlled drug deliver behavior. The DS released in simulated intestinal environment (pH 7.4) was about 20 times of that in simulated gastric environment (pH 2.0) after 12 h. UiO‐67(bpy) showed potential application prospects as an oral drug carrier. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
5. A porous Zn-based metal-organic framework for pH and temperature dual-responsive controlled drug release.
- Author
-
Lin, Wenxin, Hu, Quan, Jiang, Ke, Cui, Yuanjing, Yang, Yu, and Qian, Guodong
- Subjects
- *
POROUS materials , *METAL-organic frameworks , *PH effect , *EFFECT of temperature on metals , *CONTROLLED drugs , *DRUG delivery devices - Abstract
A porous metal-organic framework Zn-TBDA (TBDA = 4′-(1H-tetrazol-5-yl) -[1,1′-biphenyl]-3,5-dicarboxylic acid) with one-dimensional channels has been synthesized from zinc ions and bifunctional ligands. The negligible cytotoxicity of Zn-TBDA is confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and microscopy observation. The anticancer drug methotrexate (MTX) is loaded into Zn-TBDA successfully via in-situ encapsulation and the loading capability reaches about 12.59 wt% in resulting composite MTX-encapsulated Zn-TBDA. Under different physiological microenvironments, MTX-encapsulated Zn-TBDA exhibits sensitive pH and temperature dual-responsive release manners, revealing its practical value as a smart drug carrier with controlled release in certain site and improved therapeutic efficacy without any additional external fields. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
6. A biocompatible Zr-based metal-organic framework UiO-66-PDC as an oral drug carrier for pH-response release.
- Author
-
Wang, Yan, Lin, Wenxin, Yu, Shijiang, Huang, Xiajuan, Lang, Xiurui, He, Qing, Gao, Linhui, Zhu, Hongliang, and Chen, Jianjun
- Subjects
- *
METAL-organic frameworks , *DRUG carriers , *ANTI-inflammatory agents , *DRUG delivery systems , *ORGANIC bases , *X-ray powder diffraction - Abstract
A biocompatible Zr-based metal-organic framework UiO-66-PDC was synthesized basing on 2,5-pyridinedicarboxylic acid as the ligand. Powder X-ray diffraction (PXRD) was used to characterize the structure and estimate the water stability, exhibiting the ideal structure and the excellent water stability of UiO-66-PDC. The anti-inflammatory drug ibuprofen sodium (IBUNa) was selected and loaded into UiO-66-PDC to construct an oral drug delivery system. The loading amount of IBUNa reached to about 27.60 wt%. The drug release behaviors of MOF were investigated and the material exhibited pH-response release which the drugs were delivered more in intestinal environment (pH 7.4) than that in gastric environment (pH 2.0). This material indicated its potential application prospect as an oral drug carrier. A biocompatible Zr-based metal-organic framework UiO-66-PDC was synthesized and it showed excellent water stability. The anti-inflammatory drug ibuprofen sodium (IBUNa) was loaded into UiO-66-PDC to construct an oral drug delivery system. The loading amount of IBUNa reached to about 27.60 wt%. The material exhibited pH-response release which the drugs were delivered more in intestinal environment (pH 7.4) than that in gastric surrounding (pH 2.0). This material indicated its potential application prospect as an oral drug carrier. Image 1 • A biocompatible Zr-based MOF UiO-66-PDC was synthesized by a simple ligand H 2 PDC. • The drug IBUNa was loaded into UiO-66-PDC to construct an oral drug delivery system (IBUNa 27.60 wt%). • The MOF exhibited pH-response release as an oral drug carrier. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
7. A Mn-based metal-organic framework Mn-CPP for combined chemodynamic therapy and chemotherapy.
- Author
-
Yu, Hongliu, Hao, Pengyu, Si, Panpan, Wang, Bing, Shen, Qiying, Zhu, Hongliang, Lin, Wenxin, and Hu, Quan
- Subjects
- *
COMBINATION drug therapy , *METAL-organic frameworks , *HELA cells , *TUMOR microenvironment , *ANTINEOPLASTIC agents - Abstract
• Mn with Fenton-like effect as metal node to prepare a biocompatibility Mn-CPP. • Mn2+ reacted with H 2 O 2 to produce ROS to realize chemodynamic therapy through Fenton-like reaction. • Mn-CPP loaded chemotherapeutic drug DOX to construct a system for combined chemodynamic therapy and chemotherapy. A Mn-based metal-organic framework Mn-CPP was synthesized and showed excellent chemodynamic therapy (CDT) effect. DOX was selected and loaded into Mn-CPP obtaining DOX@Mn-CPP to improve the therapeutic properties. DOX@Mn-CPP exhibited better drug release behaviors in the tumor environment than that in normal environment. Besides, the material displayed good biocompatibility to L929 cells and significant effect of lethality on 4T1 cells and Hela cells. The successful fabrication of DOX@Mn-CPP provided the potential application for the combination therapy of chemodynamic therapy and chemotherapy. A Mn-based metal-organic framework Mn-CPP with good Fenton-like effect was synthesized and showed excellent CDT effect. The anticancer drug DOX was loaded to provide chemotherapeutic effect, which showed the potential application in combination therapy. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Frontiers in metal-organic framework derived bimetallic catalyst for CO2 hydrogenation.
- Author
-
Chen, Jiaxing, Xu, Wanyin, Lu, Wenwen, Lin, Wenxin, Gao, Junkuo, and Li, Qianqian
- Subjects
- *
BIMETALLIC catalysts , *METAL-organic frameworks , *CLIMATE change mitigation , *ACTIVATION energy , *CHEMICAL properties , *CARBON dioxide - Abstract
[Display omitted] • Comprehensive overview of the advantages for MOFs-derived catalysts is summarized, focusing on enhancive promoters of CO 2 hydrogenation. • The different reaction pathways of CO 2 hydrogenation are concluded, aiming to provide thoroughly understanding for catalysts synthesis. • Synergy effect of different metal-based MOFs catalysts is summarized, supplying outlooks of MOFs-based catalysts for catalytic applications. Conversion of carbon dioxide (CO 2) into high-value chemical products is one promising way to generate clean energy and climate change mitigation. However, reducing CO 2 is generally challenging due to its stable chemical properties and strong C=O bonds. The application of metal-based catalysts could significantly decrease the energy barrier for CO 2 hydrogenation. Recently, the catalysts derived from metal-organic frameworks (MOFs) have shown great potential in catalytic applications for CO 2 hydrogenation. This review provides a comprehensive overview of the advantages of MOFs-derived catalysts in catalytic applications, focusing on commonly used bimetallic catalysts and their mechanistic understanding in enhancing catalytic performances. Additionally, we provide an overview of some bimetallic-based MOFs catalysts, offering convenience and insights for researchers to directly understand the potential applications of MOFs-derived catalysts. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Construction of an anticancer system based on medi-MOF-1 and Mn ions for theranostic application.
- Author
-
Hu, Quan, Xu, Kaitao, Huang, Xiajuan, Huang, Sheng, Wang, Zhen, Lu, Wenwen, Shi, Yu, Yu, Hongliu, Duan, Wei, and Lin, Wenxin
- Subjects
- *
CANCER cell growth , *MAGNETIC resonance imaging , *METAL-organic frameworks , *MAGNETIC resonance , *TUMOR growth - Abstract
• A theranostic system Mn@medi-MOF-1 was constructed by medi-MOF-1 and Mn ions. • The system displayed T 1 -weighted magnetic resonance performance. • The system exhibited anticancer therapeutic effect via chemodynamic therapy and chemotherapy. A metal-organic framework (MOF) medi-MOF-1 containing curcumin with inhibitory effect on tumor growth was adopted for cancer therapy. And theranostic agents Mn ions were loaded to construct a theranostic system Mn@medi-MOF-1 (Mn 14.82 wt% and curcumin 31.62 wt%). In vitro, it displayed T 1 -weighted magnetic resonance performance, ideal ability of ROS production for chemodynamic therapy and stimuli-responsive drug release to inhibit cancer cell growth, indicating its potential applications for multimodal cancer theranostic. A MOF-based system containing 14.82 wt% Mn and 31.62 wt% curcumin was constructed. The system displayed good property of magnetic resonance imaging, chemodynamic therapy and chemotherapy. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Exploiting Co-C interface and graphitic carbon belts for enhanced structural stability of a porous layered Co-C catalyst for CO2 hydrogenation.
- Author
-
Chen, Jiaxing, Xu, Wanyin, Miao, Wenkang, Hao, Ronghui, Lin, Wenxin, Gao, Junkuo, and Li, Qianqian
- Subjects
- *
HYDROGENATION , *CLEAN energy , *CATALYST structure , *COMPOSITE structures , *CATALYSTS , *CATALYTIC hydrogenation - Abstract
A novel porous Co@C catalyst derived from pyrolysis of a unique layered metal-organic framework (MOF), with tunable pore sizes and thickness for CO 2 hydrogenation was reported. After preciously optimizing the structure of catalyst, the stability of the layered porous Co@C catalyst can be obviously improved, allowing it to maintain a 25% CO 2 conversion rate over an 80-hour period. Deeply investigate the dependence of the activity and stability of the Co@C catalyst on their composite structure, revealing the dual-confinement effect of stability of pore structure and ordered onion carbon belt effectively prevents the sintering of Co nanoparticles in cycles. [Display omitted] • A non-noble metal-based MOF derived RWGS catalyst was developed. • The Co-C interface and the graphene belt prevent the agglomeration of Co NPs. • The work highlights how structural adjustments can improve CO 2 hydrogenation. Addressing the urgent need for efficient CO 2 reduction, a novel Co@C catalyst was synthesized through the pyrolysis of a unique layered metal–organic framework (MOF), featuring tunable thickness, pore sizes. The CO 2 hydrogenation performance demonstrates an enhancement by an optimized structure that significantly improves stability, maintaining a 25% CO 2 conversion rate over an extended 80-hour period. The catalyst's composite structure exhibits a dual-confinement effect, where the Co-C interface and graphitic carbon belt stabilize Co nanoparticles, preventing sintering during reaction cycles. This study delves into the structural modifications necessary for catalytic optimization in CO 2 hydrogenation, offering valuable insights for designing efficient catalysts for CO 2 reduction and advancing sustainable energy solutions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. A metal-organic framework MIL-53(Fe) containing sliver ions with antibacterial property.
- Author
-
Huang, Xiajuan, Yu, Shijiang, Lin, Wenxin, Yao, Xin, Zhang, Mengyi, He, Qing, Fu, Feiya, Zhu, Hongliang, and Chen, Jianjun
- Subjects
- *
METAL-organic frameworks , *IONS , *STAPHYLOCOCCUS aureus , *ANTIBACTERIAL agents , *ESCHERICHIA coli - Abstract
The biocompatible MIL-53(Fe) was synthesized and utilized to load Ag ions via a simple impregnation resulting in an antibacterial system Ag@MIL-53(Fe). The materials were characterized by PXRD and SEM. The loading capacity and antibacterial performance of powders at different mass ratio were further investigated. The Ag ions content of Ag@MIL-53(Fe) reached to maximum (about 40.62 wt%) at the mass ratio of 1:1 which was measured by ICP. The inhibition zone radius of material (Ag 40.62 wt%) showed the optimal efficiency against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) while MIL-53(Fe) demonstrated negligible antimicrobial performance. The excellent antibacterial activity and desirable biocompatibility of Ag@MIL-53(Fe) implied its promising prospect in antibacterial. Ag ions as a typical antibacterial agent was loaded into MIL-53(Fe) via a simple impregnation method resulting in an antibacterial system Ag@MIL-53(Fe). MIL-53(Fe) exhibited the poor inhibition of S. aureus and E. coli while the obvious inhibition zone of Ag@MIL-53(Fe) was observed, the phenomena implied the excellent antibacterial behaviors of Ag@MIL-53(Fe) against both S. aureus and E. coli. [Display omitted] • A biocompatible MOF MIL-53(Fe) was synthesized. • Ag ions was loaded into MIL-53(Fe) to construct an antibacterial system Ag@MIL-53(Fe). • Ag@MIL-53(Fe) (Ag 40.62 wt%) showed optimal efficiency against both S. aureus and E. coli. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
12. A modification and selective adsorption of cationic dyes based on UiO-67.
- Author
-
Li, Yuqian, Rao, Lei, Hong, Lu, Si, Panpan, Lin, Wenxin, and Gao, Junkuo
- Subjects
- *
BASIC dyes , *TANNINS , *ADSORPTION (Chemistry) , *DYES & dyeing , *ADSORPTION capacity , *METAL compounds , *SURFACES (Technology) - Abstract
A metal polyphenol compound Fe-TA (TA is tannin) was applied for surface modification to improve the selective adsorption capacity of UiO-67 on cationic dyes. The modified material UiO-67@Fe-TA, which named UFT-X, exhibited significantly selective adsorption of cationic dye. Then the Freundlich isotherm model and quasi second-order kinetics model were employed to characterize the adsorption of UiO-67@Fe-TA, and the maximum adsorption quantity was 1415.56 mg/g. Furthermore, the adsorption efficiency remained above 80% after 6 cycles. The research provided a strategy of materials design and modification for selective adsorption on mixed dyes. UiO-67 was modified with Fe-TA and the surface of the modified material was negatively charged. It was used for adsorbing cationic dyes and repelling anionic dyes. The modified material UiO-67@Fe-TA exhibited significant selective adsorption of cationic dye. [Display omitted] • The surface of UiO-67 was successfully modified by Fe-TA. • The modification has the advantages of simple, fast and low cost. • The modified material significantly enhanced the selective adsorption of UiO-67 to cationic dyes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. A bio-platform TCN@HKUST-1 with admirable biocompatibility was applied to the antibacterial field.
- Author
-
Lu, Wenwen, Wang, Zhengfeng, Yu, Hongliu, Zheng, Jiquan, Lei, Chen, Shen, Jie, Lin, Wenxin, Gao, Junkuo, and Fu, Feiya
- Subjects
- *
METAL-organic frameworks , *BIOCOMPATIBILITY , *ANTIBACTERIAL agents , *STAPHYLOCOCCUS aureus , *ESCHERICHIA coli , *TETRACYCLINES - Abstract
A metal–organic framework HKUST-1 with admirable biocompatibility was selected to load antibiotic tetracycline hydrate (TCN) obtaining TCN@HKUST-1, which had excellent antibacterial activity against E.coli and S.aureus. TCN@HKUST-1 revealed utilizable potentiality in the field of biological antibacterial. [Display omitted] Antibiotics are powerful weapons against bacteria and the unique porous structure makes metal–organic frameworks be good choices for antibiotic delivery. In this work, metal–organic framework HKUST-1 with excellent biocompatibility was synthesized to entrap the antibacterial tetracycline hydrate (TCN) obtaining TCN@HKUST-1 system. The drug loading amount of the system was 54.90 wt%. TCN@HKUST-1 showed excellent antibacterial effects against both Staphylococcus aureus and Escherichia coli due to the antibacterial Cu2+ and TCN, revealing utilizable potentiality in the field of antibacterial application. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.