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A porous Zn-based metal-organic framework for pH and temperature dual-responsive controlled drug release.
- Source :
-
Microporous & Mesoporous Materials . Sep2017, Vol. 249, p55-60. 6p. - Publication Year :
- 2017
-
Abstract
- A porous metal-organic framework Zn-TBDA (TBDA = 4′-(1H-tetrazol-5-yl) -[1,1′-biphenyl]-3,5-dicarboxylic acid) with one-dimensional channels has been synthesized from zinc ions and bifunctional ligands. The negligible cytotoxicity of Zn-TBDA is confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and microscopy observation. The anticancer drug methotrexate (MTX) is loaded into Zn-TBDA successfully via in-situ encapsulation and the loading capability reaches about 12.59 wt% in resulting composite MTX-encapsulated Zn-TBDA. Under different physiological microenvironments, MTX-encapsulated Zn-TBDA exhibits sensitive pH and temperature dual-responsive release manners, revealing its practical value as a smart drug carrier with controlled release in certain site and improved therapeutic efficacy without any additional external fields. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13871811
- Volume :
- 249
- Database :
- Academic Search Index
- Journal :
- Microporous & Mesoporous Materials
- Publication Type :
- Academic Journal
- Accession number :
- 123505520
- Full Text :
- https://doi.org/10.1016/j.micromeso.2017.04.042