1. Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis.
- Author
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Papadimitriou N, Kazmi N, Dimou N, Tsilidis KK, Martin RM, Lewis SJ, Lynch BM, Hoffmeister M, Kweon SS, Li L, Milne RL, Sakoda LC, Schoen RE, Phipps AI, Figueiredo JC, Peters U, Dixon-Suen SC, Gunter MJ, and Murphy N
- Subjects
- Humans, Male, Female, Computers statistics & numerical data, Genome-Wide Association Study, Leisure Activities, Risk Factors, Prostatic Neoplasms genetics, Prostatic Neoplasms epidemiology, Prostatic Neoplasms etiology, Television statistics & numerical data, Breast Neoplasms genetics, Breast Neoplasms epidemiology, Breast Neoplasms etiology, Colorectal Neoplasms genetics, Colorectal Neoplasms epidemiology, Colorectal Neoplasms etiology, Mendelian Randomization Analysis, Sedentary Behavior
- Abstract
Background: Sedentary behaviours have been associated with increased risks of some common cancers in epidemiological studies; however, it is unclear if these associations are causal., Methods: We used univariable and multivariable two-sample Mendelian randomisation (MR) to examine potential causal relationships between sedentary behaviours and risks of breast, colorectal and prostate cancer. Genetic variants associated with self-reported leisure television watching and computer use were identified from a recent genome-wide association study (GWAS). Data related to cancer risk were obtained from cancer GWAS consortia. A series of sensitivity analyses were applied to examine the robustness of the results to the presence of confounding., Results: A 1-standard deviation (SD: 1.5 h/day) increment in hours of television watching increased risk of breast cancer (OR per 1-SD: 1.15, 95% confidence interval [CI]: 1.05-1.26) and colorectal cancer (OR per 1-SD: 1.32, 95% CI: 1.16-1.49) while there was little evidence of an association for prostate cancer risk (OR per 1-SD: 0.94, 95% CI: 0.84-1.06). After adjusting for years of education, the effect estimates for television watching were attenuated (breast cancer, OR per 1-SD: 1.08, 95% CI: 0.92-1.27; colorectal cancer, OR per 1-SD: 1.08, 95% CI: 0.90-1.31). Post hoc analyses showed that years of education might have a possible confounding and mediating role in the association between television watching with breast and colorectal cancer. Consistent results were observed for each cancer site according to sex (colorectal cancer), anatomical subsites and cancer subtypes. There was little evidence of associations between genetically predicted computer use and cancer risk., Conclusions: Our univariable analysis identified some positive associations between hours of television watching and risks of breast and colorectal cancer. However, further adjustment for additional lifestyle factors especially years of education attenuated these results. Future studies using objective measures of exposure can provide new insights into the possible role of sedentary behaviour in cancer development., (© 2023 World Health Organization; licensed by John Wiley & Sons Ltd. Cancer Medicine published by John Wiley & Sons Ltd.)
- Published
- 2024
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