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A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
- Source :
- Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2020
-
Abstract
- Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.<br />Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Science
General Physics and Astronomy
Sunburn
Single-nucleotide polymorphism
General Biochemistry, Genetics and Molecular Biology
Article
Cancer prevention
03 medical and health sciences
0302 clinical medicine
Cancer epidemiology
Risk Factors
Internal medicine
Neoplasms
Mendelian randomization
Vitamin D and neurology
medicine
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Risk factor
Vitamin D
Child
Cancer genetics
Multidisciplinary
business.industry
Pigmentation
Case-control study
Cancer
Mendelian Randomization Analysis
General Chemistry
medicine.disease
Confidence interval
030104 developmental biology
Case-Control Studies
Multivariate Analysis
business
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....cf9bc87b026a463b5cb1c5ed0f8e4f2e