1. Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB II): a 3 year, randomised, controlled, single-blind, multicentre clinical trial
- Author
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Andrés Iñiguez, Sebastian Reith, Manel Sabaté, Angel Cequier, Yoshinobu Onuma, Manuel de Sousa Almeida, Jan J. Piek, Gianluca Campo, Stephan Windecker, Bernard Chevalier, Yohei Sotomi, Dougal McClean, Ad J. van Boven, Dariusz Dudek, Steffen Helqvist, Michael Haude, Marcello Dominici, Patrick W. Serruys, Didier Carrié, Cardiology, Graduate School, and ACS - Amsterdam Cardiovascular Sciences
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Ischemia ,Self Expandable Metallic Stents ,Lumen (anatomy) ,Biocompatible Materials ,030204 cardiovascular system & hematology ,NO ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Absorbable Implants ,Intravascular ultrasound ,medicine ,Clinical endpoint ,Humans ,Single-Blind Method ,Everolimus ,030212 general & internal medicine ,Myocardial infarction ,610 Medicine & health ,Ultrasonography, Interventional ,medicine.diagnostic_test ,business.industry ,Medicine (all) ,Hazard ratio ,Coronary Stenosis ,Stent ,Drug-Eluting Stents ,General Medicine ,medicine.disease ,Surgery ,Treatment Outcome ,Cardiology ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
BACKGROUND No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel. METHODS The ABSORB II trial is a prospective, randomised, active-controlled, single-blind, parallel two-group, multicentre clinical trial. We enrolled eligible patients aged 18-85 years with evidence of myocardial ischaemia and one or two de-novo native lesions in different epicardial vessels. We randomly assigned patients (2:1) to receive treatment with an everolimus-eluting bioresorbable scaffold (Absorb; Abbott Vascular, Santa Clara, CA, USA) or treatment with an everolimus-eluting metallic stent (Xience; Abbott Vascular, Santa Clara, CA, USA). Randomisation was stratified by diabetes status and number of planned target lesions. At 3 year follow-up, the primary endpoint was superiority of the Absorb bioresorbable scaffold versus the Xience metallic stent in angiographic vasomotor reactivity after administration of intracoronary nitrate. The co-primary endpoint is the non-inferiority of angiographic late luminal loss. For the endpoint of vasomotion, the comparison was tested using a two-sided t test. For the endpoint of late luminal loss, non-inferiority was tested using a one-sided asymptotic test, against a non-inferiority margin of 0·14 mm. The trial is registered at ClinicalTrials.gov, number NCT01425281. FINDINGS Between Nov 28, 2011, and June 4, 2013, we enrolled 501 patients and randomly assigned them to the Absorb group (335 patients, 364 lesions) or the Xience group (166 patients, 182 lesions). The vasomotor reactivity at 3 years was not statistically different (Absorb group 0·047 mm [SD 0·109] vs Xience group 0·056 mm [0·117]; psuperiority=0·49), whereas the late luminal loss was larger in the Absorb group than in the Xience group (0·37 mm [0·45] vs 0·25 mm [0·25]; pnon-inferiority=0·78). This difference in luminal dimension was confirmed by intravascular ultrasound assessment of the minimum lumen area (4·32 mm(2) [SD 1·48] vs 5·38 mm(2) [1·51]; p
- Published
- 2016